The advantages of optical sensing for in vivo applications are compelling: non-invasiveness, non-ionizing radiation, real-time monitoring. A persistent concern, however, is the fact that the optical signal weakens as the depth of the sensor embedded within the biological tissue increases, resulting in low signal-to-noise ratio (SNR) in deep tissue measurements. On May 30, 2022, a News & Views article entitled 'A deep tissue optical sensing' was published on Nature Nanotechnology by Professor Zhang Fan from Fudan University. This article focuses on a newly reported technique for detecting optical signals in deep biological tissues, which may enable real-time monitoring and chemical sensing in living tissues.

https://www.nature.com/articles/s41565-022-01132-1