ZHOU WeiOrganic Chemistry, Associate Professor

Office Location: Room A7020, Chemistry Building, Department of Chemistry, Fudan University 2005 Songhu Road, Yangpu District, Shanghai 200438, China
Tel: 86-21-3124

  • Research Interests

  • Academic Appointments

  • Prizes and awards

  • Biography

  • Teaching

  • Key Publications

  • Microbial Transformation technologies

  • Studies on metabolic pathways of natural products and the preparation of active metabolites by using microbial conversion technologies.

  • Biological activity and mechanism study

  • A variety of disease models, such as viruses (influenza, hepatitis B, herpes, Coxsackie, respiratory syncytial) and in vivo models, bacteria (Staphylococcus aureus, Escherichia coli, Candida albicans, pneumococcal), arthritis model (acute arthritis, adjuvant arthritis, type II collagen in rheumatoid arthritis), and liver disease (chemical and immunological damage, fatty liver, liver fibrosis), etc. to carry out candidate compounds screening, mechanism studies, as well as research and development of new drugs.

  • 1999.9-2003.6    School of pharmacy, Fudan University, Under-graduate course, (Bachelor degree)

  • 2003.9-2008.6    Department of Biosynthetic Drug, School of Pharmacy, Fudan University, graduate course (Ph.D degree)

  • 2008.7-2010.3    Project manager, Zhejiang Hisun Pharmaceutical Co. Ltd (China)

  • 2010.4-2011.10  Visiting scholar, Biology Science department, Ohio University (U.S.A)

  • 2012.12-now      Lecturer, Department of Chemistry, Fudan University

  • Organic synthesis experiment

  • Medicinal chemistry

  1. Jiale Lin, Zekun Wang, Ziyue Xu, Lei Wei; Yunchang Zhang, Hui Wang, Danwei Zhang, Wei Zhou*, Yuebiao Zhang, Yi Liu*; Zhanting Li*. Water-soluble flexible organic frameworks that include and deliver proteins. Journal of the American Chemical Society, 2020-02-10, DOI: 10.1021/jacs.9b13263.

  2. Haosha Tang, Yunyan Kuang, Julan Zeng, Xiaofang Li, Wei Zhou* and Yuan Lu*. Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents. RSC Advances, 2019, 9, 31474–31482.

  3. Wei Zhou, Hai Huang, Haiyan Zhu, Pei Zhou, and Xunlong Shi*. New metabolites from the biotransformation of ginsenoside Rb1 by Paecilomyces bainier sp.229 and activities in inducing osteogenic differentiation by Wnt/β-catenin signaling activation. Journal of Ginseng Research, 2018, 42, 199-207.

  4. Huan Wang, Nanye Chen, Shuru Shen, Huiyu Li, Xiangxiang Hu, Yunkai Yang,Xiaochen Yu, Li Yea, Wei Zhou*, Meiqing Feng*. Peptide TQS169 prevents osteoporosis in rats by enhancing osteogenic differentiation and calcium absorption. Journal of Functional Foods, 2018, 49,113-21.

  5. Peng Wei, Wei Yuan, Fengfeng Xue, Wei Zhou, Ruohan Li, Datong Zhang and Tao Yi*. Deformylation reaction-based probe for in vivo imaging of HOCl. Chemical Science, 2018, 9, 495-501.

  6. Tong Liu#, Wei Zhou#, and Jie Wu*. Palladium-catalyzed direct C-H functionalization of indoles with the insertion of sulfur dioxide: synthesis of 2-Sulfonated indoles. Organic letters, 2017, 19, 6638−41.

  7. Hai Huang#, Wei Zhou#, Haiyan Zhu, Pei Zhou, and Xunlong Shi*. Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs. Toxicology and Applied Pharmacology, 2017, 323, 36-43.

  8. Wei Zhou, Xiaohui Liu, Pei Zhang, Pei Zhou, and Xunlong Shi*. Effect analysis of mineral salt concentrations on nosiheptide production by Streptomyces actuosus Z-10 using response surface methodology. Molecules, 2014, 19, 15507-20.

  9. Wei Zhou, Xiaohui Liu, Li Ye, Meiqing Feng, Pei Zhou, and Xunlong Shi*. The biotransformation of astragalosides by a novel acetyl esterase from Absidia corymbifera AS2. Process Biochemistry, 2014, 49, 1464-71.

Address: Chemistry Building, Department of Chemistry, Fudan University
2005 Songhu Road, Yangpu District, Shanghai 200438, China  Tel: 86-21-31242791
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