ZHANG QiOrganic Chemistry/Chemical Biology, Professor

Office Location: Room A5019, Chemistry Building, Department of Chemistry, Fudan University 2005 Songhu Road, Yangpu District, Shanghai 200438, China
Tel: 86-21-31248172
Website (Research Group URL):

  • Research Interests

  • Academic Appointments

  • Prizes and awards

  • Biography

  • Teaching

  • Key Publications

    • Biosynthesis and chemical synthesis of bioactive peptide natural products

    • Discovery of novel antibiotics using omics-based approaches

    • Radical SAM enzymology

    • 2011  Reaxys PhD Prize Finalist (Elsevier)

    • 2010  Excellent Student Awards, Chinese Academy of Sciences

    • 1999.9-2003.7 BS in Chemistry, Fudan University, Shanghai, China

    • 2005.9-2010.7 Ph.D in Organic Chemistry (Thesis Advisor: Prof. Shen Ben and Wen Liu) Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences, China

    • Thesis title: Functional characterization and mechanistic study of NosL, a radical S-adenosylmethionine enzyme involved in nosiheptide biosynthesis

    • 2010.7-2011.1 Research Associate, SIOC, Chinese Academy of Sciences

    • 2011.2-2014.5 Postdoctoral Research Fellow (Advisor: Prof. Wilfred A. van der Donk) Department of Chemistry, University of Illinois at Urbana-Champaign

    • Project: Biosynthesis and Engineering of Lanthipeptides

    • 2014.5-Present Professor of Chemistry, Fudan University                         

    • Introduction of chemical biology and synthetic biology (TBD)

    1. Characterization of a C3 deoxygenation pathway reveals a key branch point in aminoglycoside biosynthesisMeinan Lv, Xinjian Ji, Junfeng Zhao, Yongzhen Li, Chen Zhang, Li Su, Wei Ding, Zixin Deng, Yi Yu* and Qi Zhang*J. Am. Chem. Soc. 2016, In press.

    2. Biosynthetic investigation of phomopsins revealed a widespread pathway for ribosomal natural products in filamentous fungiWei Ding, Wan-Qiu Liu, Youli Jia, Yongzhen Li, Wilfred A van der Donk*, and Qi Zhang*Proc. Natl. Acad. Sci. 2016, 113, 3521-6

    3. Mechanistic Insights into the Radical S-adenosyl-l-methionine Enzyme NosL From a Substrate Analogue and the Shunt Products.Xianjian Ji, Yongzhen Li, Youli Jia, Wei Ding, Qi Zhang*Angew Chem Int Ed Engl. 2016, 55, 3334-7

    4. Substrate-Tuned Catalysis of the Radical S-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide BiosynthesisXianjian Ji, Yongzhen Li, Wei Ding, Qi Zhang*Angew Chem Int Ed Engl. 2015, 54, 9021-4

    5. Substrate-controlled stereochemistry in enzyme catalysisWei Ding, Yongzhen Li, and Qi Zhang*ACS Chem Biol. 2015, 10, 1590-8

    6. Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in ActinobacteriaQi Zhang, James R. Doroghazi, Xiling Zhao, Mark C. Walker, and Wilfred A. van der Donk*Appl. Environ. Microbiol., 2015, 81, 4339-50

    7. High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesisQi Zhang, Xiao Yang, Huan Wang, and Wilfred A. van der Donk*ACS Chem. Biol. 2014, 9, 2686-2694

    8. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MSQi Zhang, Manuel A. Ortega, Yanxiang Shi, Huan Wang, Joel O. Melby, Douglas A. Mitchell, and Wilfred A. van der Donk*   Proc. Natl. Acad. Sci. 2014, 111,12031-12036

    9. Aromatic Polyketides Produced by Bacterial Iterative Type I Polyketide Synthases      Qi Zhang, Bo Pang, Wei Ding, and Wen Liu*      ACS Catal., 2013, 3, 1439–1447

    10. Biosynthesis of thiopeptide antibiotics and their pathway engineering     Qi Zhang and Wen Liu*     Nat. Prod. Rep., 2013, 30, 218-226

    11. Evolution of lanthipeptide synthetasesQi Zhang, Yi Yu, Juan E. Vélasquez, and Wilfred. A. van der Donk*Proc. Natl. Acad. Sci., 2012, 109, 18361-18366.

    12. Catalytic promiscuity of a bacterial α-N-methyltransferaseQi Zhang and Wilfred. A. van der Donk*FEBS Lett., 2012, 586, 3391-3397

    13. Radical-Mediated Enzymatic Methylation: A Tale of Two SAMSQi Zhang, Wilfred. A. van der Donk*, and Wen Liu*Acc. Chem. Res., 2012, 45, 555-64.

    14. Complex Biotransformations Catalyzed by Radical S-Adenosylmethionine EnzymesQi Zhang* and Wen Liu*J. Biol. Chem., 2011, 286, 30245-30252.

    15. Characterization of NocL Involved in Thiopeptide Nocathiacin I biosynthesis: A [4Fe-4S] Cluster and the Catalysis of a Radical S-Adenosylmethionine EnzymeQi Zhang, Dandan Chen, Jin Lin, Rijing, Liao, Wei Tong, and Wen Liu*J. Biol. Chem., 2011, 286, 21287-21294.

    16. Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination.Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen, and Wen Liu*Nat. Chem. Biol., 2011, 7, 154-160. [This paper was highlighted in (1) Science. 2011, 331, 1366; (2) Nat. Chem. Biol., 2011, 7, 133-134; (3) Faculty 1000,; (4) Nature China 2011, doi: 10.1038/nchina.2011.9]

Address: Chemistry Building, Department of Chemistry, Fudan University
2005 Songhu Road, Yangpu District, Shanghai 200438, China  Tel: 86-21-31242791
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