WANG WenningChemical Biology, Professor
Office Location: Room A3020, Chemistry Building, Department of Chemistry, Fudan University 2005 Songhu Road, Yangpu District, Shanghai 200438, China
Tel: 86-21-31243985
Website (Research Group URL):

  • Research Interests

  • Academic Appointments

  • Prizes and awards

  • Biography

  • Teaching

  • Key Publications

    • Computational biology and structural biology

    • Molecular simulation of conformational changes of membrane proteins

    • The structure and function of proteins related with signal transduction and cell polarity

    • Croucher Foundation Fellowship for Mainland Scholar

    • Shuguang scholarship, Shanghai Education Foundation

    • 1986.9-1990.7    B. Sc., Department of Chemistry, Fudan University

    • 1990.9-1995.12  Ph. D., Department of Chemistry, Fudan University

    • 1995.12-1996.3  Postdoctoral Fellow, Institute of Molecular Science, Japan

    • 1996.4-2000.4    Lecturer, Department of Chemistry, Fudan University

    • 2000.4-2005.4    Associate Professor, Department of Chemistry, Fudan University

    • 2005.4-              Professor, Department of Chemistry, Fudan University

    • 2008.5-              Joint PI, Institute of Biomedical Sciences, Fudan University

    • “Introduction to Spectroscopy”

    • “Topics in Modern Chemistry”

    1. Weng J., Wang W.(2020) Dynamic Multivalent Interactions of Intrinsically Disordered Proteins. Curr. Opin. Struct. Biol. 62, 9-13.

    2. Wang D., Weng J.*, Wang W.*. (2019) Glycerol Transport through the Aquaglyceroporin GlpF: Bridging Dynamics and Kinetics with Atomic Simulation. Chem. Sci. 10, 6957-6965.

    3. Wu S., Wang D., Liu J., Feng Y., Weng J.*, Li Y., Gao X., Liu J.*, Wang, W.* (2017) The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins. Angew. Chemie. Int. Ed. 56, 7515-7519. (F1000 recommended)

    4. Feng Y., Zhang L., Wu S., Gao X., Liu J.*, Huang X.*, Wang W.* (2016) Multiple Metastable Conformations Co-exist in the Apo-Glutamine Binding Protein Structural Ensemble Revealed by Tightly Coupled Experimental and Computational Approaches. Angew. Chem. Int. Ed. 55, 13990-13994.

    5. Jia M., Shan Z., Yang Y., Liu C., Li J., Luo Z., Zhang M., Cai Y.*, Wen W.*, Wang W.* (2015) The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nat. Commun. 6, 8381.

    6. Pan Z, Zhu J, Shang Y, Wei Z, Jia M, Xia C, Wen W, Wang W.*, Zhang M* (2013) An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs. Structure, 21, 1007-1017.

    7. Jia M., Li J., Zhu J., Wen W., Zhang M*, Wang W.* (2012) Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gai subunits in G-coupled heterotrimeric proteins. J. Biol. Chem.287, 36766-36776.

    8. Zhu J., Wen W., Zheng Z., Shang Y., Wei Z., Xiao Z., Pan Z., Du Q.*, Wang W.*, Zhang M.* (2011) LGN/mInsc and LGN/NuMA complexes structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gai/LGN/NuMA pathways. Mol. Cell, 43, 418-431.

    9. Wang W.*, Weng J., Zhang X., Liu M., Zhang M.* (2009) Creating conformational entropy by increasing inter-domain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95 J. Am. Chem. Soc. 131, 787-796.

    10. Fu H., Liu Z., Li Z., Wang W.*, Fan K.* (2006) “Periodic density functional theory study of propane oxidative dehydrogenation over V2O5(001) surface”, J. Am. Chem. Soc. 128, 11114-11123.

Address: Chemistry Building, Department of Chemistry, Fudan University
2005 Songhu Road, Yangpu District, Shanghai 200438, China  Tel: 86-21-31242791
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