TAN XiangshiStudent biology, professor, doctoral tutor

Office Location: Room A4023, Chemistry Building, Department of Chemistry, Fudan University 2005 Songhu Road, Yangpu District, Shanghai 200438, China
Tel: 86-21-31249208

  • Research Interests

  • Academic Appointments

  • Prizes and awards

  • Biography

  • Teaching

  • Key Publications

    • Bioinorganic Chemistry, Chemical Biology of Metalloproteins and Metalloenzymes;

    • Structural Basis and mechanism for human soluble guanylate cyclase to mediate NO-signalling; Regulation mechanism of metal ions homeostasis in AD brain;

    • Trafficking, metabolism and regulation of metal ions in cells;

    • Functional design of metalloproteins and metalloenzymes.

    • Faculty of 1000 member in Biochemistry 2013

    • Member of Sigma Xi, 2002

    • JSPS and STA research fellowship, 1998-2000

    • Royal Society research fellowship, 1997

    • 2007-present    Fudan University, Professor

    • 2000-2007        Texas A & M University, Research Scientist

    • 1998-2000        Japan,Ibaraki University,JASP Research Scientist

    • 1997-1998        UK,Edinburgh University, Royal Society Research Scientist

    • 1996-1997        France, CEA-Grenoble, Postdoctoral Research Associate

    • 1993-1996        PhD,  Nanjing University

    • 1989-1992        M.S.,  East China Normal University

    • 1982-1986        B.S.,  Liaocheng University

    • Graduate students: 《BioinorganicChemistry/ Protein Chemistry》, 《Progress in Bioinorganic Chemistry》

    • Undergraduate students: 《Metals in Biology and Diseases》, 《Research Design and Training 》

    1. Jie Pan, Qiming Xu, Ying-Wu Lin, Fangfang Zhong and Xiangshi Tan*, Human soluble guanylate cyclase as a nitric oxide sensor for NO-signalling reveals a novel function of nitrite reductase,Chem. Commun., 49, 7454-7456,2013.

    2. Xiaoping Lv, Wei Li, Ying Luo, Dandan Wang, Cuiqing Zhu, Zhong-Xian Huang and Xiangshi Tan*, Exploring the differences between mouse mAβ1–42 and human hAβ1–42 for Alzheimer's disease related properties and neuronal cytotoxicity,Chem. Commun., 49, 5865-5867,2013.

    3. Yi Liu, Qingli Wang, Yaozhu Wei, Ying-Wu Lin, Wei Li, Ji-Hu Su, Zhen Wang, Yang Tian, Zhong-Xian Huang and Xaingshi Tan*, Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase, Chem. Commun., 49, 1452-145, 2013.

    4. Wei Li, Hongfei Wang, Zheng Chen, Qing Ye, Yang Tian, Xin Xu, Zhong-xian Huang, Pingwei Li, Xiangshi Tan*, Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile, Chem. Commun., 50, 584-586, 2014.

    5. Ying Luo, Yuxia Xu, Qingui Bao, Zhichhun Ding, Cuiqing Zhu, Zhong-Xian Huang, Xiangshi Tan*, The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of A1–42 with Cu ions, J Biol Inorg Chem, 18(1):39-47, 2013.

    6. Yi Liu, Xiaofei Zhu, Feng Wang, Pingwei Li, Zhong-xian Huang and Xiangshi Tan*, Probing the role of the bridging C509 between the [Fe4S4] cubane and [NipNid] centre in the A-Cluster of Acetyl-Coenzyme A Synthase, Chem. Commun., 47(4), 1291-1293, 2011.

    7. Yi Liu, Feng Wang, Pingwei Li, and Xiangshi Tan*, Insights into the Mechanistic Role of the [Fe4S4] Cubane in the A-Cluster {[Fe4S4]-(SR)-[NipNid]} of Acetyl-Coenzyme A Synthase, ChemBioChem., 12(9):1417-1421, 2011.

    8. Xiangshi Tan, Marlene Martinho, Audria Stubna, Paul A. Lindahl, Eckard Münk, Mössbauer Evidence for an Exchange-Coupled {[Fe4S4]1+:Nip1+} A-cluster in Isolated Alpha Subunits of Acetyl-Coenzyme A Synthase/Carbon Monoxide Dehydrogenase,  J. Am. Chem. Soc. , 130, 6712-6713, 2008.

    9. Xiangshi Tan, Ivan V. Surovtsev, and Paul A. Lindahl, Kinetics of CO Insertion and Acetyl Group Transfer Steps, and a Model of the Acetyl-CoA Synthase Catalytic Mechanism, J. Am. Chem. Soc. 128(37), 12331-12338, 2006.

    10. Xiangshi Tan, Huay-Keng Loke, Shawn Fitch and Paul A. Lindahl, The Tunnel of the Acetyl-CoA Synthase/Carbon Monoxide Dehydrogenase Regulates Delivery of CO to the Active Site, J. Am. Chem. Soc. 127, 5833-5836, 2006.

Address: Chemistry Building, Department of Chemistry, Fudan University
2005 Songhu Road, Yangpu District, Shanghai 200438, China  Tel: 86-21-31242791
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