学科进展系列报告

Interrupted Cross Coupling

         Michael Kevin Brown

          印第安纳大学化学系

Stereospecific cross-coupling of chiral alkyl metal intermediates is a recognized challenge in modern organic synthesis. Here an alternative strategy is presented in which a chiral alkyl metal is generated as a catalytic intermediate by boryl-metalation of an alkene followed by cross coupling. This interrupted cross coupling represents an attractive approach in chemical synthesis because two new bonds and two new stereocenters are generated in a single operation.  In addition, due to the synthetic versatility of the carbon-boron bond, a variety of structures can be readily prepared, thus representing a general approach toward carbofunctionalization of alkenes.  The scope, mechanistic details, and application to complex molecule synthesis will be discussed.

时间：2019年5月14日上午10:00

地点：江湾校区化学楼A7032

邀请人：张俊良  教授（021-31249180）