张琪
  • 研究兴趣

  • 学术任职

  • 获奖情况

  • 学习工作经历

  • 授课情况

  • 代表性论文或专著

  • 活性多肽类化合物的化学生物学研究

  • 特殊金属酶学机制。

  • 《Frontiers in Chemistry》杂志副主编

  • 《Science》等多个杂志特约审稿人

  • 2011 Reaxy PhD Prize, finalist

  • 1999.9年9月至2003年7月    复旦大学化学系获得学士学位

  • 2005年9月至2010年7月      中科院上海有机化学研究所获得博士学位

  • 2010年7月至2011年2月      中科院上海有机化学研究所工作,助理研究员

  • 2011年2月至2014年5月      美国伊利诺伊大学香槟分校,博士后

  • 2014年5月至今                   复旦大学化学系,教授, 博士生导师

  • 化学生物学导论CHEM130091.01

    1.  Characterization of a C3 deoxygenation pathway reveals a key branch point in aminoglycoside biosynthesis
    Meinan Lv, Xinjian Ji, Junfeng Zhao, Yongzhen Li, Chen Zhang, Li Su, Wei Ding, Zixin Deng, Yi Yu* and Qi Zhang*
    J. Am. Chem. Soc. 2016, In press.

     

    2.  Biosynthetic investigation of phomopsins revealed a widespread pathway for ribosomal natural products in filamentous fungi
    Wei Ding, Wan-Qiu Liu, Youli Jia, Yongzhen Li, Wilfred A van der Donk*, and Qi Zhang*
    Proc. Natl. Acad. Sci. 2016, 113, 3521-6


    3.  Mechanistic Insights into the Radical S-adenosyl-l-methionine Enzyme NosL From a Substrate Analogue and the Shunt Products.
    Xianjian Ji, Yongzhen Li, Youli Jia, Wei Ding, Qi Zhang*
    Angew Chem Int Ed Engl. 2016, 55, 3334-7

     

    4.  Substrate-Tuned Catalysis of the Radical S-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis
    Xianjian Ji, Yongzhen Li, Wei Ding, Qi Zhang*
    Angew Chem Int Ed Engl. 2015, 54, 9021-4

     

    5.  Substrate-controlled stereochemistry in enzyme catalysis
    Wei Ding, Yongzhen Li, and Qi Zhang*
    ACS Chem Biol. 2015, 10, 1590-8

     

    6. Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in Actinobacteria
    Qi Zhang, James R. Doroghazi, Xiling Zhao, Mark C. Walker, and Wilfred A. van der Donk*
    Appl. Environ. Microbiol., 2015, 81, 4339-50

     

    7. High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis
    Qi Zhang, Xiao Yang, Huan Wang, and Wilfred A. van der Donk*
    ACS Chem. Biol. 2014, 9, 2686-2694

     

    8. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
    Qi Zhang, Manuel A. Ortega, Yanxiang Shi, Huan Wang, Joel O. Melby, Douglas A. Mitchell, and Wilfred A. van der Donk*
    Proc. Natl. Acad. Sci. 2014, 111,12031-12036

     

    9. Aromatic Polyketides Produced by Bacterial Iterative Type I Polyketide Synthases
    Qi Zhang, Bo Pang, Wei Ding, and Wen Liu*
    ACS Catal., 2013, 3, 1439–1447

     

    10. Biosynthesis of thiopeptide antibiotics and their pathway engineering
    Qi Zhang and Wen Liu*
    Nat. Prod. Rep., 2013, 30, 218-226

     

    11. Evolution of lanthipeptide synthetases
    Qi Zhang, Yi Yu, Juan E. Vélasquez, and Wilfred. A. van der Donk*
    Proc. Natl. Acad. Sci., 2012, 109, 18361-18366.

     

    12. Catalytic promiscuity of a bacterial α-N-methyltransferase
    Qi Zhang and Wilfred. A. van der Donk*
    FEBS Lett., 2012, 586, 3391-3397


    13. Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS
    Qi Zhang, Wilfred. A. van der Donk*, and Wen Liu*
    Acc. Chem. Res., 2012, 45, 555-64.

     

    14. Complex Biotransformations Catalyzed by Radical S-Adenosylmethionine Enzymes
    Qi Zhang* and Wen Liu*
    J. Biol. Chem., 2011, 286, 30245-30252.

     

    15. Characterization of NocL Involved in Thiopeptide Nocathiacin I biosynthesis: A [4Fe-4S] Cluster and the Catalysis of a Radical S-Adenosylmethionine Enzyme
    Qi Zhang, Dandan Chen, Jin Lin, Rijing, Liao, Wei Tong, and Wen Liu*
    J. Biol. Chem., 2011, 286, 21287-21294.

     

    16. Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination.
    Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen, and Wen Liu*
    Nat. Chem. Biol., 2011, 7, 154-160. [This paper was highlighted in (1) Science. 2011, 331, 1366; (2) Nat. Chem. Biol., 2011, 7, 133-134; (3) Faculty 1000, F1000.com/8771961; (4) Nature China 2011, doi: 10.1038/nchina.2011.9]