1. Characterization of a C3 deoxygenation pathway reveals a key branch point in aminoglycoside biosynthesis
Meinan Lv, Xinjian Ji, Junfeng Zhao, Yongzhen Li, Chen Zhang, Li Su, Wei Ding, Zixin Deng, Yi Yu* and Qi Zhang*
J. Am. Chem. Soc. 2016, In press.
2. Biosynthetic investigation of phomopsins revealed a widespread pathway for ribosomal natural products in filamentous fungi
Wei Ding, Wan-Qiu Liu, Youli Jia, Yongzhen Li, Wilfred A van der Donk*, and Qi Zhang*
Proc. Natl. Acad. Sci. 2016, 113, 3521-6
3. Mechanistic Insights into the Radical S-adenosyl-l-methionine Enzyme NosL From a Substrate Analogue and the Shunt Products.
Xianjian Ji, Yongzhen Li, Youli Jia, Wei Ding, Qi Zhang*
Angew Chem Int Ed Engl. 2016, 55, 3334-7
4. Substrate-Tuned Catalysis of the Radical S-Adenosyl-L-Methionine Enzyme NosL Involved in Nosiheptide Biosynthesis
Xianjian Ji, Yongzhen Li, Wei Ding, Qi Zhang*
Angew Chem Int Ed Engl. 2015, 54, 9021-4
5. Substrate-controlled stereochemistry in enzyme catalysis
Wei Ding, Yongzhen Li, and Qi Zhang*
ACS Chem Biol. 2015, 10, 1590-8
6. Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in Actinobacteria
Qi Zhang, James R. Doroghazi, Xiling Zhao, Mark C. Walker, and Wilfred A. van der Donk*
Appl. Environ. Microbiol., 2015, 81, 4339-50
7. High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis
Qi Zhang, Xiao Yang, Huan Wang, and Wilfred A. van der Donk*
ACS Chem. Biol. 2014, 9, 2686-2694
8. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
Qi Zhang, Manuel A. Ortega, Yanxiang Shi, Huan Wang, Joel O. Melby, Douglas A. Mitchell, and Wilfred A. van der Donk*
Proc. Natl. Acad. Sci. 2014, 111,12031-12036
9. Aromatic Polyketides Produced by Bacterial Iterative Type I Polyketide Synthases
Qi Zhang, Bo Pang, Wei Ding, and Wen Liu*
ACS Catal., 2013, 3, 1439–1447
10. Biosynthesis of thiopeptide antibiotics and their pathway engineering
Qi Zhang and Wen Liu*
Nat. Prod. Rep., 2013, 30, 218-226
11. Evolution of lanthipeptide synthetases
Qi Zhang, Yi Yu, Juan E. Vélasquez, and Wilfred. A. van der Donk*
Proc. Natl. Acad. Sci., 2012, 109, 18361-18366.
12. Catalytic promiscuity of a bacterial α-N-methyltransferase
Qi Zhang and Wilfred. A. van der Donk*
FEBS Lett., 2012, 586, 3391-3397
13. Radical-Mediated Enzymatic Methylation: A Tale of Two SAMS
Qi Zhang, Wilfred. A. van der Donk*, and Wen Liu*
Acc. Chem. Res., 2012, 45, 555-64.
14. Complex Biotransformations Catalyzed by Radical S-Adenosylmethionine Enzymes
Qi Zhang* and Wen Liu*
J. Biol. Chem., 2011, 286, 30245-30252.
15. Characterization of NocL Involved in Thiopeptide Nocathiacin I biosynthesis: A [4Fe-4S] Cluster and the Catalysis of a Radical S-Adenosylmethionine Enzyme
Qi Zhang, Dandan Chen, Jin Lin, Rijing, Liao, Wei Tong, and Wen Liu*
J. Biol. Chem., 2011, 286, 21287-21294.
16. Radical-Mediated Enzymatic Carbon Chain Fragmentation-Recombination.
Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen, and Wen Liu*
Nat. Chem. Biol., 2011, 7, 154-160. [This paper was highlighted in (1) Science. 2011, 331, 1366; (2) Nat. Chem. Biol., 2011, 7, 133-134; (3) Faculty 1000, F1000.com/8771961; (4) Nature China 2011, doi: 10.1038/nchina.2011.9]