G-L
黄则度 有机化学，副教授，博士生导师
研究兴趣
学术任职
获奖情况
学习工作经历
授课情况
代表性论文或专著
新颖酶催化和生物催化反应的发现与应用
手性药物与手性技术的研究
合成生物学
2003.9-2007.6 浙江大学化学系本科，获得学士学位
2007.9-2012.8 加拿大阿尔伯塔大学化学系研究生，获得博士学位
2012.11-2016.10 美国伊利诺伊大学香槟分校，博士后
2016.11-2022.11 复旦大学化学系，青年研究员
2022.12起 复旦大学化学系，副教授
本科生必修课程《有机化学》
本科生必修课程《有机化学实验I》
Wu, X.; Yang, L.; Liu, Z.; Zhang, K.; Huang, Z.;* Chen, F.* Ene-Reductase-Catalyzed Enantioselective Desymmetrization of Cyclohexadienones: Straightforward Access to All-Carbon Quaternary Stereocenters. ACS Catal. 2024, 14, 6194-6202.
Zhu, K.; Jiang, M.; Ye, B.; Zhang, G.; Li, W.; Tang, P.; Huang, Z.;* Chen, F.* A Unified Strategy to Prostaglandins: Chemoenzymatic Total Synthesis of Cloprostenol, Bimatoprost, PGF2, Fluprostenol, and Travoprost Guided by Biocatalytic Retrosynthesis. Chem. Sci. 2021, 12, 10362-10370.
Hu, P.; Wu, X.; Zhang, Y.; Liu, M.; Tao, Y.; Huang, Z.;* Chen, F.* Engineered Ketoreductase-Catalyzed Stereoselective Reduction of Ethyl 2’-Ketopantothenate and Its Analogues: Chemoenzymatic Synthesis of D-Pantothenic Acid. Green Chem.2024, 26, 2124-2134.
Zhang, Y.; Liu, M.; Yang, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Batch and Continuous Flow Asymmetric Synthesis of Anabolic-Androgenic Steroids via a Single-Cell Biocatalytic Δ1-Dehydrogenation and C17-Carbonyl Reduction Cascade. Green Chem.2023, 25, 3223-3235.
Liu, J.; Wu, X.; Li, Z.; Huang, Z.;* Chen, F.* Engineered Monoamine Oxidase-Catalyzed Deracemization of Sterically Hindered Acylaminomethyl-tetrahydroisoquinoline: Asymmetric Synthesis of (R)‑(−)-Praziquantel and Its Analogues. ACS Sustainable Chem. Eng.2023, 11, 7552-7559.
Yue, X.; Li, Y.; Sang, D.; Tao, Y.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Syn-Aryl-(2S,3R)-2-Chloro-3-Hydroxy Esters via an Engineered Ketoreductase-Catalyzed Dynamic Reductive Kinetic Resolution. Chin. Chem. Lett. 2023, 34, 108178.
Li, Y.; Yue, X.; Li, Z.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Sterically Hindered 1-Substituted Tetrahydro-β-carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development. Org. Lett. 2023, 25, 1285-1289.
Yue, X.; Li, Y.; Liu, M.; Sang, D.; Huang, Z.;* Chen, F.* Biocatalytic Dynamic Reductive Kinetic Resolution of Aryl α-Chloro β-Keto Esters: Divergent, Stereocontrolled Synthesis of Diltiazem, Clentiazem, and Siratiazem. Chem. Commun.2022, 58, 9010-9013.
Li, Z.; Wang, Z.; Wang, Y.; Wu, X.; Lu, H.; Huang, Z.;* Chen, F.* Substituent Position-Controlled Stereoselectivity in Enzymatic Reduction of Diaryl- and Aryl(heteroaryl)methanones. Adv. Synth. Catal.2019, 361, 1859-1865.
Li, Z.; Yang, H.; Liu, J.; Huang, Z.;* Chen, F.* Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018-2020). Chem. Rec. 2021, 21, 1611-1630.