EN

黄则度 有机化学,副教授,博士生导师

  • 研究兴趣

  • 学术任职

  • 获奖情况

  • 学习工作经历

  • 授课情况

  • 代表性论文或专著

  • 新颖酶催化和生物催化反应的发现与应用

  • 手性药物与手性技术的研究

  • 合成生物学



  • 2003.9-2007.6           浙江大学化学系本科,获得学士学位

  • 2007.9-2012.8           加拿大阿尔伯塔大学化学系研究生,获得博士学位

  • 2012.11-2016.10        美国伊利诺伊大学香槟分校,博士后

  • 2016.11-2022.11        复旦大学化学系,青年研究员

  • 2022.12起                  复旦大学化学系,副教授

  • 本科生必修课程《有机化学》

  • 本科生必修课程《有机化学实验I》

  1. Zhu, K.; Jiang, M.; Ye, B.; Zhang, G.; Li, W.; Tang, P.; Huang, Z.;* Chen, F.* A Unified Strategy to Prostaglandins: Chemoenzymatic Total Synthesis of Cloprostenol, Bimatoprost, PGF2, Fluprostenol, and Travoprost Guided by Biocatalytic Retrosynthesis. Chem. Sci. 2021, 12, 10362-10370.

  2. Zhang, Y.; Liu, M.; Yang, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Batch and Continuous Flow Asymmetric Synthesis of Anabolic-Androgenic Steroids via a Single-Cell Biocatalytic Δ1-Dehydrogenation and C17-Carbonyl Reduction Cascade. Green Chem. 2023, 25, 3223-3235.

  3. Liu, J.; Wu, X.; Li, Z.; Huang, Z.;* Chen, F.* Engineered Monoamine Oxidase-Catalyzed Deracemization of Sterically Hindered Acylaminomethyl-tetrahydroisoquinoline: Asymmetric Synthesis of (R)‑(−)-Praziquantel and Its Analogues. ACS Sustain. Chem. Eng. 2023, doi.org/10.1021/acssuschemeng.3c00985.

  4. Li, Y.; Yue, X.; Li, Z.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Sterically Hindered 1Substituted Tetrahydro-β-carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development. Org. Lett. 2023, 25, 1285-1289.

  5. Yue, X.; Li, Y.; Liu, M.; Sang, D.; Huang, Z.;* Chen, F.* Biocatalytic Dynamic Reductive Kinetic Resolution of Aryl -Chloro -Keto Esters: Divergent, Stereocontrolled Synthesis of Diltiazem, Clentiazem, and Siratiazem. Chem. Commun. 2022, 58, 9010-9013.

  6. Li, Z.; Wang, Z.; Wang, Y.; Wu, X.; Lu, H.; Huang, Z.;* Chen, F.* Substituent Position-Controlled Stereoselectivity in Enzymatic Reduction of Diaryl- and Aryl(heteroaryl)methanones. Adv. Synth. Catal. 2019, 361, 1859-1865.

  7. Wu, X.; Huang, Z.;* Wang, Z.; Li, Z.; Wang, J.; Lin, J.;* Chen, F.* Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogues Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight. J. Org. Chem. 2020, 85, 5598-5614.

  8. Wu, X.; Li, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Engineered Cyclohexylamine Oxidase with Improved Activity and Stereoselectivity for Asymmetric Synthesis of a Bulky Dextromethorphan Precursor and Its Analogues. ChemCatChem 2022, 14, doi.org/10.1002/cctc.202101970.

  9. Li, Z.; Yang, H.; Liu, J.; Huang, Z.;* Chen, F.* Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018-2020). Chem. Rec. 2021, 21, 1611-1630.

  10. Hu, C.; Ye, B.; Huang, Z.;* Chen, F.* Development Of an Engineered Ketoreductase with Improved Activity, Stereoselectivity and Relieved Substrate Inhibition for Enantioselective Synthesis of a Key (R)--Lipoic Acid Precursor. Mol. Catal. 2022, 522, 112208.

地址:上海市杨浦区淞沪路2005号复旦大学江湾校区化学楼   邮编:200438   电话:86-21-31242791
版权所有 © 复旦大学化学系 2014     技术支持:维程互联