Research Interests

• developing new synthetic reactions of conjugated enynes and small rings.

• Design and synthesis of novel chiral ligands and their applications in asymmetric catalysis.

• Developing novel catalyst for polymerization.

Academic Appointments

• Member of Chinese Chemical Society

Prizes and awards

• 2014, National Science Fund for Distinguished Young Scholars

• 2014, ACP-Lectureship Award

• 2013, Distinguished Lectureship Award

• 2012, Synfacts/Synlett/Synthesis Journal Award

• 2009, Chinese Chemical Society for young Scientists

Biography

• 1993.9-1997.6            BSc, Department of Chemistry, Tianjing University

• 1997.9-2002.6            Ph.D., Shanghai Institute of Organic Chemistry (SIOC), CAS, Shanghai, China

• 2002.7-2003.9            Research Chemist, SIOC

• 2003.10-2004.12           Humboldt Fellow, Institute of Organic Chemistry, University of Cologne, Germany

• 2005.2-2006.10           Postdoc, Department of Chemistry, University of Chicago, USA

• 2006.12-2017.9           Professor and Vice Dean, School of Chemistry and Molecular Engineering, East China Normal University

• 2017.10-               Professor, Department of Chemistry, Fudan University

Teaching

• Organometallic Chemistry

Key Publications

1. Y. Liu, W. Li, J. Zhang* Chiral ligands designed in China. Natl. Sci. Rev. 2017, 4, 326–358.

2. Y. Wang, P.-C. Zhang, X. Di, Q. Dai, Z.-M. Zhang, J. Zhang* Gold-Catalyzed Asymmetric Intramolecular Cyclization of N-Allenamides for the Synthesis of Chiral Tetrahydrocarbolines. Angew. Chem. Int. Ed. 2017, 56, 15905–15909.

3. S. Xu, Z.-M. Zhang, B. Xu, B. Liu, Y. Liu*, J. Zhang* Enantioselective Regiodivergent Synthesis of Chiral Pyrrolidines with Two Quaternary Stereocenters via Ligand-Controlled Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloadditions. J. Am. Chem. Soc. 2018, 140, 2272–2283.

4. L. Wang, M. Chen, P.-C. Zhang, W. Li, J. Zhang* Palladium/PC-Phos-Catalyzed Enantioselective Arylation of General Sulfenate Anions: Scope and Synthetic Applications. J. Am. Chem. Soc. 2018, 140, 3467–3473.

5. Z.-M. Zhang, B. Xu, Y. Qian, L. Wu, Y. Wu, L. Zhou, Y. Liu, J. Zhang* Palladium-Catalyzed Enantioselective Reductive Heck Reactions: Convenient Access to 3,3-Disubstituted 2,3-Dihydrobenzofuran. Angew. Chem. Int. Ed. 2018, 57, 10373–10377.

6. H. Wang, L. Zhang, Y. Tu, R. Xiang, Y.-L. Guo*, J. Zhang* Phosphine-Catalyzed Difunctionalization of β-Fluoroalkyl α,β-Enones: A Direct Approach to β-Amino α-Diazo Carbonyl Compounds. Angew. Chem. Int. Ed. 2018, 57, 15787–15791.

7. H. Wang, J. Zhan, Y. Tu, J. Zhang* Phosphine-Catalyzed Enantioselective Dearomative [3+2]-Cycloaddition of 3-Nitroindoles and 2-Nitrobenzofurans. Angew. Chem. Int. Ed. 2019, 58, 5422–5426.

8. Z.-M. Zhang, B. Xu, L. Wu, L. Zhou, D. Ji, Y. Liu, Z. Li*, J. Zhang* Palladium/XuPhos-Catalyzed Enantioselective Carboiodination of Olefin-Tethered Aryl Iodides. J. Am. Chem. Soc. 2019, 141, 8110–8115.

9. P.-C. Zhang, J. Han, J. Zhang* Pd/PC-Phos-Catalyzed Enantioselective Intermolecular Denitrogenative Cyclization of Benzotriazoles with Allenes and N-Allenamides. Angew. Chem. Int. Ed. 2019, 58, 11444–11448. (VIP)

10. Z.-M. Zhang, B. Xu, L. Wu, Y. Wu, Y. Qian, L. Zhou, Y. Liu, J. Zhang* Enantioselective Dicarbofunctionalization of Unactivated Alkenes by Palladium-Catalyzed Tandem Heck/Suzuki Coupling Reaction. Angew. Chem. Int. Ed. 2019, 58, 14653–14659.

11. C. Zhu, H. Chu, G. Li, S. Ma*, J. Zhang* Pd-Catalyzed Enantioselective Heck Reaction of Aryl Triflates and Alkynes. J. Am. Chem. Soc. 2019, 141, 19246–19251.

12. Q. Dai, W. Li, Z. Li, J. Zhang* P-Chiral Phosphines Enabled by Palladium/Xiao-Phos-Catalyzed Asymmetric P–C Cross-Coupling of Secondary Phosphine Oxides and Aryl Bromides. J. Am. Chem. Soc. 2019, 141, 20556–20564.

13. H. Wang, H. Luo, Z.-M. Zhang, W.-F. Zheng, Y. Yin, H. Qian*, J. Zhang*, S. Ma* Pd-Catalyzed Enantioselective Syntheses of Trisubstituted Allenes via Coupling of Propargylic Benzoates with Organoboronic Acids. J. Am. Chem. Soc. 2020, 142, 9763–9771.

14. L. Wang, K. Zhang, Y. Wang, W. Li, M. Chen, J. Zhang* Enantioselective Synthesis of Isoxazolines Enabled by Palladium-Catalyzed Carboetherification of Alkenyl Oximes. Angew. Chem. Int. Ed.2020, 59, 4421–4427.

15. L. Zhou, S. Li, B. Xu, D. Ji, L. Wu, Y. Liu, Z.-M. Zhang*, J. Zhang* Enantioselective Difunctionalization of Alkenes by a Palladium-Catalyzed Heck/Sonogashira Sequence. Angew. Chem. Int. Ed. 2020, 59, 2769–2775.

16. Q. Dai, L. Liu, Y. Qian, W. Li, J. Zhang* Construction of P-Chiral Alkenylphosphine Oxides through Highly Chemo-, Regio-, and Enantioselective Hydrophosphinylation of Alkynes. Angew. Chem. Int. Ed.2020, 59, 20645–20650.

17. H. Chu, J. Cheng, J. Yang, Y.-L. Guo*, J. Zhang * Asymmetric Dearomatization of Indole via Palladium/PC-Phos-Catalyzed Dynamic Kinetic Transformation. Angew. Chem. Int. Ed. 2020, 59, 21991–21996. (Hot Paper)

18. T.-Y. Lin, Z. Pan, Y. S. Zhu, H.-H. Wu, Y. Liu, Z. Li*, J. Zhang* Design and Synthesis of TY-Phos and Application in Palladium-Catalyzed Enantioselective Fluoroarylation of gem-Difluoroalkenes. Angew. Chem. Int. Ed. 2020, 59, 22957−22962.

19. D. Qian, J. Zhang* Yne–Enones Enable Diversity-Oriented Catalytic Cascade Reactions: A Rapid Assembly of Complexity. Acc. Chem. Res.2020, 53, 2358–2371.

20. Z. Pan, W. Li, S. Zhu, F. Liu, H.-H. Wu, J. Zhang* Palladium/TY-Phos-Catalyzed Asymmetric Intermolecular α-Arylation of Aldehydes with Aryl Bromides. Angew. Chem. Int. Ed.2021, 60, 18542–18546. (Hot Paper)

21. P.-C. Zhang, Y.-L. Li, J. He, H.-H. Wu*, Z. Li*, J. Zhang* Simultaneous construction of axial and planar chirality by gold/TY-Phos-catalyzed asymmetric hydroarylation. Nat. Commun.2021, 12, 4609.

22. Y.-L. Li, P.-C. Zhang, H.-H. Wu, J. Zhang* Palladium-Catalyzed Asymmetric Tandem Denitrogenative Heck/Tsuji–Trost of Benzotriazoles with 1,3-Dienes. J. Am. Chem. Soc. 2021, 143, 13010–13015.

23. G. Zhao, Y. Wu, H.-H. Wu, J. Yang*, J. Zhang* Pd/GF-Phos-Catalyzed Asymmetric Three-Component Coupling Reaction to Access Chiral Diarylmethyl Alkynes. J. Am. Chem. Soc. 2021, 143, 17983–17988.

24. Q. Dai, L. Liu*, J. Zhang* Palladium/Xiao-Phos-Catalyzed Kinetic Resolution of sec-Phosphine Oxides by P-Benzylation. Angew. Chem. Int. Ed. 2021, 60, 27247–27252.

25. B. Xu, D. Ji, L. Wu, L. Zhou, Y. Liu, Z.-M. Zhang*, J. Zhang* Palladium/Xu-Phos-catalyzed enantioselective cascade Heck/remote C(sp2) –H alkylation reaction. Chem2022, 8, 836–849.