Research Interests

• Oxidative Coupling of Unactivated C-H Bonds

• Synthesis and Property Research of Novel Polyaniline Materials

• Photo Induced C-H Bond Oxidation

• Novel Bioorthogonal Chemistry

Biography

• 1998-2002        BSc，Nankai University

• 2002-2007        PhD, Shanghai Institute of Organic Chemistry, CAS.

• 2008-2013        Associated Professor, Shanghai Institute of Technology

• 2014-2016        Postdoc Investigator, Fudan University

• 2017-2018        Visiting Investigator, The Scripps Research Institute

• 2019-            Associated Professor, Fudan University

Teaching

• Organic Chemistry Experiments

Key Publications

1. Y. Liao, Y. Zhou, Z. Zhang, J. Fan, F. Liu, Z. Shi. Intramolecular Oxidative Coupling between Unactivated Aliphatic C-H and Aryl C-H Bonds. Org. Lett. 23, 1251-1257 (2021).

2. H. Diao, Z. Shi, F. Liu. Biaryl Construction Base on Nickel-Catalyzed C-O Bond Activation. Syn. lett. 32, A-S (2021).

3. C. Wang, F. Liu, Z. Shi. Homogeneous functionalization of light alkanes. Sci. Sin. Chem. 50, 756-765 (2020).

4. F. Liu, H. Jiang, Y. Zhou, Z. Shi. Direct Transformation of Arenols Based on C-O Activation. Chin. J. Chem. 38, 855-863 (2020).

5. F. Liu, H. Wang, S. Li, G. Bare, J. Moses, P. Wu, K. Sharpless. Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4) Derived Connective Hubs For Bioconjugation to DNA and Proteins. Angew. Chem. Int. Ed. 58, 8029-8033 (2019).

6. R. Gou, Y. Zhang, S. W. Wu, F. Liu. Synthesis of Polysubstituted 3-Chalcogenated Indoles through Copper(I)-Catalyzed Three Component Domino-Reactions. Syn. Lett. 30, 207-212 (2019).

7. Z. P. Chen, Y. Zhou, M.Z. Shui, F. Liu. CuI Catalyzed Domino Coupling-Cyclization of 2-Iodo-Phenols and 1-Alkynes to the Synthesis of 2-Substituted Benzo[b]furans/furo-pyridines. Tetrahedron Lett. 60, 133-136 (2019).

8. X.H. Pan, S.P. Bai, W.S. Yu, D. Ding, D.X. Zhao, F. Liu. Efficient Synthesis of 3-R-Boc-amino-4-(245-trifluorophenyl)butyric Acid. Synth. Commun. 45, 1451-1456 (2015).

9. D. Ding, X.H. Pan, W.S. Yu, X.J. Li, S.K. Chen, F. Liu. An Cost-Effective and Safe Process of L-cis-45-Methanoproline Amide The Key Synthetic Intermediate of Saxagliptin via an Improved Simmons-Smith Reaction. Heterocycles 91, 719-725 (2015).

10. X.H. Pan, S.Y. Xu, R. Huang, W.S. Yu, F. Liu. A Facile Six-Step Process for the Synthesis of (3S5S)‑3-Isopropyl-5-((2S4S)‑4-isopropyl- 5-oxo-tetra- hydrofuran-2-yl)-2-oxopyrrolidine-1-carboxylic Acid tert- Butyl Ester The Key Synthetic Intermediate of Aliskiren. Org. Pro. Res. Dev. 19, 611-617 (2015).

11. Liu, F.; Zhang, Y.; Pan, X. Synthesis of Multisubstituted Benzofurans. CN105669618B.

12. Liu, F.; Zhang, Y.; Pan, X. Chen, X. Synthesis of Multisubstituted Indoles. CN105237458B.