EN
dayong.yang@foxmail.com
化学楼A4006室
Research Interests
Nucleic acid chemistry
DNA biofunctional materials
Advanced technology for cancer diagnosis and therapeutics
Synthetic biology
Academic Appointments
The National Science Fund for Distinguished Young Scholars (2022)
The National Science Fund for Excellent Young Scholars (2015)
Prizes and awards
Advisory board member of Advanced Functional Materials
Editorial board member of Chinese Chemical Letters
Biography
1998-2002 Bachelor's degree in Chemistry, Huazhong University of Science and Technology
2002-2005 Master's degree in Chemistry, Huazhong University of Science and Technology
2005-2008 PhD, National Center for Nanoscience and Technology, Chinese Academy of Sciences
2008-2010 Assistant Professor, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences
2010-2014 Postdoctoral fellow, Cornell University, USA,
2014-2015 Postdoctoral fellow, University of Nijmegen, Netherlands
2015- Tianjin University, Professor
Teaching
DNA synthesis
Nucleic acid-based functional materials
Key Publications
Nachuan Song+, Hongjin Li+, Chi Yao*, Dayong Yang*, Dynamic Chemistry of DNA-Based Nanoassemblies in Living Cells, Accounts of Chemical Research, 2024, 57, 2763.
Sen Yang+, Junlin Wu+, Zhongyu Wang, Yu Cheng, Rui Zhang, Chi Yao*, Dayong Yang*, A Smart DNA Hydrogel Enables Synergistic Immunotherapy and Photodynamic Therapy of Melanoma. Angewandte Chemie International Edition, 2024, in press.
Nachuan Song+, Xiaoting Fan+, Xiaocui Guo+, Jianpu Tang, Hongjin Li, Ruoyu Tao, Fengqin Li, Junru Li, Dayong Yang*, Chi Yao*, Peifeng Liu*, A DNA/Upconversion Nanoparticle Complex Enables Controlled Co-Delivery of CRISPR-Cas9 and Photodynamic Agents for Synergistic Cancer Therapy. Advanced Materials, 2024, in press.
Yanfei Guo, Siqi Li, Zhaobin Tong, Jianpu Tang, Rui Zhang, Zhaoyue Lv, Nachuan Song, Dayong Yang*, Chi Yao*, Telomerase-Mediated Self-Assembly of DNA Network in Cancer Cells Enabling Mitochondrial Interference. Journal of the American Chemical Society, 2023, 145, 23859.
Nachuan Song+, Yiwen Chu+, Shuai Li, Yuhang Dong, Xiaoting Fan, Jianpu Tang, Yanfei Guo, Guangshuai Teng, Chi Yao*, Dayong Yang*, Cascade Dynamic Assembly/Disassembly of DNA Nanoframework Enabling the Controlled Delivery of CRISPR-Cas9 System. Science Advances, 2023, 9, eadi3602.
Zhaoyue Lv+, Mengxue Huang+, Jing Yang+, Peiran Li, Lele Chang, Qianyun Tang, Xiaojing Chen, Shengqi Wang*, Chi Yao*, Peifeng Liu*, Dayong Yang*, A Smart DNA-Based Nanosystem Containing Ribosome-Regulating siRNA for Enhanced mRNA Transfection. Advanced Materials, 2023, 35, 2300823.
Jianpu Tang+, Xuemei Jia+, Qian Li+, Zhen Cui, Aiqi Liang, Bin Ke, Dayong Yang*, Chi Yao*, A DNA-Based Hydrogel for Exosome Separation and Biomedical Applications. Proceedings of the National Academy of Sciences of the United States of America, 2023, 120, e2303822120.
Fengqin Li+, Junru, Li+, Weiqiang Yang+, Shuai Yang, Congshuo Chen, Ling Du, Junyang Mei, Qianyun Tang, Xiaojing Chen, Chi Yao, Dayong Yang*, Xiaolei Zuo*, Peifeng Liu*, Framework-Hotspot Enhanced Trans Cleavage of CRISPR-Cas12a for Clinical Samples Detection. Angewandte Chemie International Edition, 2023, 62, e202305536.
Chi Yao+*, Yuwei Xu+, Jianpu Tang+, Pin Hu, Hedong Qi, Dayong Yang*, Dynamic Assembly of DNA-Ceria Nanocomplex in Living Cells Generates Artificial Peroxisome. Nature Communications, 2022, 13, 7739.
Chi Yao+, Junhan Ou+, Jianpu Tang+, Dayong Yang*, DNA Supramolecular Assembly on Micro/Nanointerfaces for Bioanalysis. Accounts of Chemical Research, 2022, 55, 2043.
Yuhang Dong+, Feng Li+, Zhaoyue Lv, Shuai Li, Meihe Yuan, Nachuan Song, Jinqiao Liu, Dayong Yang*, Lysosome Interference Enabled by Proton-Driven Dynamic Assembly of DNA Nanoframeworks inside Cells. Angewandte Chemie International Edition, 2022, 61, e202207770.
Feng Li+, Yujie Liu+, Yuhang Dong, Yiwen Chu, Nachuan Song, Dayong Yang*, Dynamic Assembly of DNA Nanostructures in Living Cells for Mitochondrial Interference. Journal of the American Chemical Society, 2022, 144, 4667.
Huaixin Zhao+, Linghui Li+, Feng Li*, Chunxia Liu, Mengxue Huang, Jiao Li, Feng Gao, Xinhua Ruan, Dayong Yang*, An Energy-Storing DNA-Based Nanocomplex for Laser-Free Photodynamic Therapy. Advanced Materials, 2022, 34, 2109920.
Feng Li+, Nachuan Song+, Yuhang Dong, Shuai Li, Linghui Li, Yujie Liu, Zhemian Li, Dayong Yang*, A Proton-Activatable DNA-Based Nanosystem Enables Co-Delivery of CRISPR/Cas9 and DNAzyme for Combined Gene Therapy. Angewandte Chemie International Edition, 2022, 61, e202116569.
Chi Yao+, Hedong Qi+, Xuemei Jia, Yuwei Xu, Zhaobin Tong, Zi Gu, Dayong Yang*, A DNA Nanocomplex Containing Cascade DNAzymes and Promoter-Like Zn-Mn-Ferrite for Combined Gene/Chemo-Dynamic Therapy. Angewandte Chemie International Edition, 2022, 61, e202113619.
Jinpeng Han, Yanfei Guo, Hang Wang, Kunyu Zhang, Dayong Yang*, Sustainable Bioplastic Made from Biomass DNA and Ionomers. Journal of the American Chemical Society, 2021, 143, 19486.
Chi Yao+, Chenxu Zhu+, Jianpu Tang, Junhan Ou, Rui Zhang, Dayong Yang*, T Lymphocyte-Captured DNA Network for Localized Immunotherapy. Journal of the American Chemical Society, 2021, 143, 19330.
Feng Li+, Zhaoyue Lv+, Xue Zhang, Yuhang Dong, Xiaohui Ding, Zhemian Li, Shuai Li, Chi Yao, Dayong Yang*, Supramolecular Self-Assembled DNA Nanosystem for Synergistic Chemical and Gene Regulations on Cancer Cells. Angewandte Chemie International Edition, 2021, 60, 25557.
Chi Yao+, Rui Zhang+, Jianpu Tang, Dayong Yang*, Rolling Circle Amplification (RCA)-Based DNA Hydrogel. Nature Protocols, 2021, 16, 5460.
Feng Li+, Wenting Yu+, Jiaojiao Zhang, Yuhang Dong, Xiaohui Ding, Xinhua Ruan, Zi Gu, Dayong Yang*, Spatiotemporally Programmable Cascade Hybridization of Hairpin DNA in Polymeric Nanoframework for Precise siRNA Delivery. Nature Communications, 2021, 12, 1138.
Xiaocui Guo+, Feng Li+, Chunxia Liu, Yi Zhu, Nannan Xiao, Zi Gu, Dan Luo, Jianhui Jiang, Dayong Yang*, Construction of Organelle-Like Architecture by Dynamic DNA Assembly in Living Cells. Angewandte Chemie International Edition, 2020, 59, 20651.
Yuhang Dong+, Chi Yao+, Yi Zhu, Lu Yang, Dan Luo, Dayong Yang*, DNA Functional Materials Assembled from Branched DNA: Design, Synthesis and Applications. Chemical Reviews, 2020, 120, 9420.
Dong Wang, Jinhui Cui, Mingzhe Gan, Zhaohui Xue, Jing Wang, Peifeng Liu, Yue Hu, Yehudah Pardo, Shogo Hamada, Dayong Yang*, Dan Luo*, Transformation of Biomass DNA into Biodegradable Materials from Gels to Plastics for Reducing Petrochemical Consumption. Journal of the American Chemical Society, 2020, 142, 10114.
Feng Li+, Shuai Li+, Xiaocui Guo, Yuhang Dong, Chi Yao, Yangping Liu, Yuguang Song, Xiaoli Tan, Lizeng Gao, Dayong Yang*, Chiral Carbon Dots Mimicking Topoisomerase I to Enantioselectively Mediate the Topological Rearrangement of Supercoiled DNA Enantioselectively. Angewandte Chemie International Edition, 2020, 59, 11087.
Chi Yao+, Han Tang+, Weijian Wu, Jianpu Tang, Weiwei Guo, Dan Luo, Dayong Yang*, Double Rolling Circle Amplification Generates Physically Cross-linked DNA Network for Stem Cell Fishing. Journal of the American Chemical Society, 2020, 142, 3422.
Jianpu Tang+, Chi Yao+, Zi Gu, Sunghwan Jung, Dan Luo, Dayong Yang*, Super-Soft and Super-Elastic DNA Robot with Magnetically Driven Navigational Locomotion for Cell Delivery in Confined Space. Angewandte Chemie International Edition, 2020, 59, 2490.
Xiaocui Guo+, Feng Li+, Lihui Bai, Wenting Yu, Xue Zhang, Yi Zhu, Dayong Yang*, Gene Circuit Compartment on Nanointerface Facilitatating Cascade Gene Expression. Journal of the American Chemical Society, 2019, 141, 19171.
