EN
Wenning Wang
Physical Chemistry, Chemical Biology
Professor
wnwang@fudan.edu.cn
Room A3020, Chemistry Building, Department of Chemistry, Fudan University 2005 Songhu Road, Yangpu District, Shanghai 200438, China
021-31243985
Research Interests
Computational biology and structural biology
Molecular simulation of conformational changes of membrane proteins
The structure and function of proteins related with signal transduction and cell polarity
Prizes and awards
Croucher Foundation Fellowship for Mainland Scholar
Shuguang scholarship, Shanghai Education Foundation
Biography
1986.9-1990.7 B. Sc., Department of Chemistry, Fudan University
1990.9-1995.12 Ph. D., Department of Chemistry, Fudan University
1995.12-1996.3 Postdoctoral Fellow, Institute of Molecular Science, Japan
1996.4-2000.4 Lecturer, Department of Chemistry, Fudan University
2000.4-2005.4 Associate Professor, Department of Chemistry, Fudan University
2005.4- Professor, Department of Chemistry, Fudan University
2008.5- Joint PI, Institute of Biomedical Sciences, Fudan University
Teaching
“Introduction to Spectroscopy”
“Topics in Modern Chemistry”
Key Publications
Weng J., Wang W.* (2020) Dynamic Multivalent Interactions of Intrinsically Disordered Proteins. Curr. Opin. Struct. Biol. 62, 9-13.
Wang D., Weng J.*, Wang W.*. (2019) Glycerol Transport through the Aquaglyceroporin GlpF: Bridging Dynamics and Kinetics with Atomic Simulation. Chem. Sci. 10, 6957-6965.
Wu S., Wang D., Liu J., Feng Y., Weng J.*, Li Y., Gao X., Liu J.*, Wang, W.* (2017) The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins. Angew. Chemie. Int. Ed. 56, 7515-7519. (F1000 recommended)
Feng Y., Zhang L., Wu S., Gao X., Liu J.*, Huang X.*, Wang W.* (2016) Multiple Metastable Conformations Co-exist in the Apo-Glutamine Binding Protein Structural Ensemble Revealed by Tightly Coupled Experimental and Computational Approaches. Angew. Chem. Int. Ed. 55, 13990-13994.
Jia M., Shan Z., Yang Y., Liu C., Li J., Luo Z., Zhang M., Cai Y.*, Wen W.*, Wang W.* (2015) The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division. Nat. Commun. 6, 8381.
Pan Z, Zhu J, Shang Y, Wei Z, Jia M, Xia C, Wen W, Wang W.*, Zhang M* (2013) An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs. Structure, 21, 1007-1017.
Jia M., Li J., Zhu J., Wen W., Zhang M*, Wang W.* (2012) Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gai subunits in G-coupled heterotrimeric proteins. J. Biol. Chem.287, 36766-36776.
Zhu J., Wen W., Zheng Z., Shang Y., Wei Z., Xiao Z., Pan Z., Du Q.*, Wang W.*, Zhang M.* (2011) LGN/mInsc and LGN/NuMA complexes structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gai/LGN/NuMA pathways. Mol. Cell, 43, 418-431.
Wang W.*, Weng J., Zhang X., Liu M., Zhang M.* (2009) Creating conformational entropy by increasing inter-domain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95 J. Am. Chem. Soc. 131, 787-796.
Fu H., Liu Z., Li Z., Wang W.*, Fan K.* (2006) “Periodic density functional theory study of propane oxidative dehydrogenation over V2O5(001) surface”, J. Am. Chem. Soc. 128, 11114-11123.
