黄则度

有机化学

副教授,博士生导师

huangzedu@fudan.edu.cn

复旦大学手性分子催化与合成工程中心A207室

13817525134

研究兴趣

  • 新颖酶催化和生物催化反应的发现与应用

  • 手性药物与手性技术的研究

  • 合成生物学

学习工作经历

  • 2003.9-2007.6         浙江大学化学系本科,获得学士学位

  • 2007.9-2012.8         加拿大阿尔伯塔大学化学系研究生,获得博士学位

  • 2012.11-2016.10        美国伊利诺伊大学香槟分校,博士后

  • 2016.11-2022.11        复旦大学化学系,青年研究员

  • 2022.12起                 复旦大学化学系,副教授

授课情况

  • 本科生必修课程《有机化学》

  • 本科生必修课程《有机化学实验I》

代表性论文或专著

  • Wu, X.; Yang, L.; Liu, Z.; Zhang, K.; Huang, Z.;* Chen, F.* Ene-Reductase-Catalyzed Enantioselective Desymmetrization of Cyclohexadienones: Straightforward Access to All-Carbon Quaternary Stereocenters. ACS Catal. 2024, 14, 6194-6202.

  • Zhu, K.; Jiang, M.; Ye, B.; Zhang, G.; Li, W.; Tang, P.; Huang, Z.;* Chen, F.* A Unified Strategy to Prostaglandins: Chemoenzymatic Total Synthesis of Cloprostenol, Bimatoprost, PGF2, Fluprostenol, and Travoprost Guided by Biocatalytic Retrosynthesis. Chem. Sci. 2021, 12, 10362-10370.

  • Hu, P.; Wu, X.; Zhang, Y.; Liu, M.; Tao, Y.; Huang, Z.;* Chen, F.* Engineered Ketoreductase-Catalyzed Stereoselective Reduction of Ethyl 2’-Ketopantothenate and Its Analogues: Chemoenzymatic Synthesis of D-Pantothenic Acid. Green Chem.2024, 26, 2124-2134.

  • Zhang, Y.; Liu, M.; Yang, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Batch and Continuous Flow Asymmetric Synthesis of Anabolic-Androgenic Steroids via a Single-Cell Biocatalytic Δ1-Dehydrogenation and C17-Carbonyl Reduction Cascade. Green Chem.2023, 25, 3223-3235.

  • Liu, J.; Wu, X.; Li, Z.; Huang, Z.;* Chen, F.* Engineered Monoamine Oxidase-Catalyzed Deracemization of Sterically Hindered Acylaminomethyl-tetrahydroisoquinoline: Asymmetric Synthesis of (R)‑(−)-Praziquantel and Its Analogues. ACS Sustainable Chem. Eng.2023, 11, 7552-7559.

  • Yue, X.; Li, Y.; Sang, D.; Tao, Y.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Syn-Aryl-(2S,3R)-2-Chloro-3-Hydroxy Esters via an Engineered Ketoreductase-Catalyzed Dynamic Reductive Kinetic Resolution. Chin. Chem. Lett. 2023, 34, 108178.

  • Li, Y.; Yue, X.; Li, Z.; Huang, Z.;* Chen, F.* Asymmetric Synthesis of Sterically Hindered 1-Substituted Tetrahydro-β-carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development. Org. Lett. 2023, 25, 1285-1289.

  • Yue, X.; Li, Y.; Liu, M.; Sang, D.; Huang, Z.;* Chen, F.* Biocatalytic Dynamic Reductive Kinetic Resolution of Aryl α-Chloro β-Keto Esters: Divergent, Stereocontrolled Synthesis of Diltiazem, Clentiazem, and Siratiazem. Chem. Commun.2022, 58, 9010-9013.

  • Li, Z.; Wang, Z.; Wang, Y.; Wu, X.; Lu, H.; Huang, Z.;* Chen, F.* Substituent Position-Controlled Stereoselectivity in Enzymatic Reduction of Diaryl- and Aryl(heteroaryl)methanones. Adv. Synth. Catal.2019, 361, 1859-1865.  

  • Li, Z.; Yang, H.; Liu, J.; Huang, Z.;* Chen, F.* Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018-2020). Chem. Rec. 2021, 21, 1611-1630.