研究兴趣

• 核酸及其修饰的检测方法开发，如RNA结合蛋白靶点测序、核酸修饰测序等  

• 新型RNA空间分辨率测序技术  

• 转录与转录后调控的功能研究

获奖情况

• 2024年，上海市海外人才项目

学习工作经历

• 2010.9-2014.6，山东大学泰山学堂，获化学学士学位  

• 2014.9-2019.7，北京大学化学与分子工程学院，获化学生物学博士学位 (导师：贾桂芳教授)  

• 2019.9-2025.2，美国芝加哥大学化学系，博士后 (导师：何川教授)  

• 2025.3起，复旦大学化学系，青年研究员

学术任职

授课情况

代表性论文或专著

• Yu Xiao#, Yan-Ming Chen#, Zhongyu Zou, Chang Ye, Xiaoyang Dou, Jinjun Wu, Chang Liu, Shun Liu, Hao Yan, Pingluan Wang, Tie-Bo Zeng, Qinzhe Liu, Jingyi Fei, Weixin Tang, Chuan He*. Profiling of RNA-binding protein binding sites by in situ reverse transcription-based sequencing. Nature Methods, 2024, 21(2): 247-258. (Highlighted in Nature Methods. ARTR-seq for determining RNA-binding protein target sites through in situ reverse transcription. Nature Methods 21, 164–165, 2024, #第一作者或共同第一作者,*通讯作者)

• Yu Xiao#, Ye Wang, Qian Tang, Lianhuan Wei, Xiao Zhang, Guifang Jia*. An elongation- and ligation-based qPCR amplification method for the radiolabeling-free detection of locus-specific N⁶-methyladenosine modification. Angewandte Chemie International Edition, 2018, 57(49): 15995-16000.

• Xiaoyang Dou#, Yu Xiao#, Chao Shen#, Kitty Wang#, Tong Wu, Chang Liu, Yini Li, Xianbin Yu, Jun Liu, Qing Dai, Kinga Pajdzik, Chang Ye, Ruiqi Ge, Boyang Gao, Jianhua Yu, Shuying Sun, Mengjie Chen*, Jianjun Chen*, Chuan He*. RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation. Nature Cell Biology, 2023, 25(9): 1359-1368. (Highlighted in Nature Cell Biology. A non-coding m⁶A reader promotes leukaemia. Nature Cell Biology 25, 1247–1249, 2023)

• Jinjun Wu#, Yu Xiao#, Yunzheng Liu#, Li Wen, Chuanyang Jin, Shun Liu, Sneha Paul, Chuan He, Oded Regev*, Jingyi Fei*. Dynamics of RNA localization to nuclear speckles are connected to splicing efficiency. Science Advances, 2024, 10: eadp7727.

• Yini Li#, Xiaoyang Dou#, Jun Liu#, Yu Xiao#, Zhe Zhang, Lindsey Hayes, Rong Wu, Xiujuan Fu, Yingzhi Ye, Bing Yang, Lyle W. Ostrow, Chuan He*, Shuying Sun*. Globally reduced N⁶-methyladenosine (m⁶A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration. Nature Neuroscience, 2023, 26(8): 1328-1338 (Highlighted in Nature Neuroscience. Dysregulation of RNA methylation contributes to neurodegeneration. Nature Neuroscience26, 1322–1323, 2023)

• Xiaoyang Dou#, Lulu Huang#, Yu Xiao#, Chang Liu, Yini Li, Xinning Zhang, Lishan Yu, Ran Zhao, Lei Yang, Chuan Chen, Xianbin Yu, Boyang Gao, Meijie Qi, Yawei Gao, Bin Shen, Shuying Sun, Chuan He*, Jun Liu*. METTL14 is a chromatin regulator independent of its RNA N⁶-methyladenosine methyltransferase activity. Protein & Cell, 2023, 14(9): 683-697.

• Miao Wang#, Yu Xiao#, Yan Li#, Xiaoying Wang, Suzhen Qi, Ye Wang, Liuwei Zhao, Kai Wang, Wenjun Peng, Guan-Zheng Luo*, Xiaofeng Xue*, Guifang Jia*, Wu Liming*. RNA m⁶A Modification Functions in Larval Development and Caste Differentiation in Honeybee (Apis mellifera). Cell Reports, 2021, 34(1): 108580-108580.

• Xiao Zhang#, Lian-Huan Wei#, Yuxin Wang#, Yu Xiao#, Jun Liu, Wei Zhang, Ning Yan, Gubu Amu, Xinjing Tang, Liang Zhang*, Guifang Jia*. Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(8): 2919-2924.

• Zhongyu Zou#, Xiaoyang Dou#, Ying Li#, Zijie Zhang, Juan Wang, Boyang Gao, Yu Xiao, Yiding Wang, Lijie Zhao, Chenxi Sun, Qinzhe Liu, Xianbin Yu, Hao Wang, Juyeong Hong, Qing Dai, Feng-Chun Yang, Mingjiang Xu*, Chuan He*. RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis. Nature, 2024 634: 986–994.

• Chang Liu#, Xiaoyang Dou#, Yutao Zhao#, Linda Zhang, Lisheng Zhang, Qing Dai, Jun Liu, Tong Wu, Yu Xiao, Chuan He*. IGF2BP3 promotes mRNA degradation through internal m⁷G modification. Nature Communications, 2024, 15: 7421.

• Qiong Yu#, Shun Liu#, Lu Yu#, Yu Xiao, Shasha Zhang, Xueping Wang, Yingying Xu, Hong Yu, Yulong Li, Junbo Yang, Jun Tang, Hong-Chao Duan, Lian-Huan Wei, Haiyan Zhang, Jiangbo Wei, Qian Tang, Chunling Wang, Wutong Zhang, Ye Wang, Peizhe Song, Qiang Lu, Wei Zhang, Shunqing Dong, Baoan Song*, Chuan He*, Guifang Jia*. RNA demethylation increases the yield and biomass of rice and potato plants in field trials. Nature Biotechnology, 2021, 39(12): 1581-1588. (Highlighted in Nature Genetics. RNA demethylation for increased crop yields. Nature Genetics 53, 1275, 2021)

• Yuru Wang#, Zijie Zhang, Caraline Sepich-Poore, Lisheng Zhang, Yu Xiao, Chuan He*. LEAD-m⁶A-seq for Locus-Specific Detection of N⁶-Methyladenosine and Quantification of Differential Methylation. Angewandte Chemie International Edition, 2021, 60(2): 873-880.

• Ye Wang#, Yu Xiao, Shunqing Dong, Qiong Yu, Guifang Jia*. Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine. Nature Chemical Biology, 2020, 16(8): 896-903.

• Lian-Huan Wei#, Peizhe Song, Ye Wang, Zhike Lu, Qian Tang, Qiong Yu, Yu Xiao, Xiao Zhang, Hong-Chao Duan, Guifang Jia*. The m⁶A reader ECT2 controls trichome morphology by affecting mRNA stability in Arabidopsis. Plant Cell, 2018, 30(5): 968-985.

• Jiantong Dong#, Tongbo Wu, Yu Xiao, Lu Chen, Lei Xu, Mengyuan Li, Meiping Zhao*. Target-triggered transcription machinery for ultra-selective and sensitive fluorescence detection of nucleoside triphosphates in one minute. Biosensors and Bioelectronics, 2018, 100: 333-340.

• Jiantong Dong#, Tongbo Wu, Yu Xiao, Lei Xu, Simin Fang, Meiping Zhao*. A fuel-limited isothermal DNA machine for the sensitive detection of cellular deoxyribonucleoside triphosphates. Chemical Communications, 2016, 52(80): 11923-11926.

• Yu Xu#, Zheng Jiang, Yu Xiao, Ting-Ting Zhang, Jun-Ying Miao, Bao-Xiang Zhao*. A new fluorescent turn-on chemodosimeter for mercury ions in solution and its application in cells and organisms. Analytica Chimica Acta, 2014, 807: 126-134.

• Yu Xu#, Zheng Jiang, Yu Xiao, Fu-Zhen Bi, Jun-Ying Miao, Bao-Xiang Zhao*. A new fluorescent pH probe for extremely acidic conditions. Analytica Chimica Acta, 2014, 820: 146-151.

• Meng-Meng Li#, Fang-Wu Wang, Xiao-Yun Wang, Ting-Ting Zhang, Yu Xu, Yu Xiao, Jun-Ying Miao, Bao-Xiang Zhao*. A new turn-on fluorescence probe for Zn(2+) in aqueous solution and imaging application in living cells. Analytica Chimica Acta, 2014, 826: 77-83.

• Meng-Meng Li#, Wen-Bo Zhao, Ting-Ting Zhang, Wei-Liu Fan, Yu Xu, Yu Xiao, Jun-Ying Miao, Bao-Xiang Zhao*. A new thiophenyl pyrazoline fluorescent probe for Cu2+ in aqueous solution and imaging in live cell. Journal of fluorescence, 2013, 23: 1263-1269.