EN
Ying Zhang
Chemical Biology
Professor
ying@fudan.edu.cn
A4022, Chemistry Building
021- 54237618
Research Interests
Mass spectrometry analysis methods for protein post-translational modifications (e.g. glycosylation et al.)
Mass spectrometry analysis methods for glycomics
Chemical proteomics and functional proteomics
Omics analysis methods and their applications
Prizes and awards
2021 Youth Scholar of“Chang Jiang Scholars Program”
2019 Shanghai Pujiang Talent
2015 Shanghai Rising Star in Science and Technology
Biography
2023.03- Professor, Department of Chemistry, Fudan University
2018.12-2023.02 Professor, Institutes of Biomedical Sciences, Fudan University
2017.01-2017.12 Visiting Scholar, Department of Biochemistry, Purdue University
2012.12-2018.11 Associate Professor, Institutes of Biomedical Sciences, Fudan University
2009.07-2012.11 Assistant Professor, Institutes of Biomedical Sciences, Fudan University
2004.09-2009.06 PhD, Department of Chemistry, Fudan University
Academic Appointments
Member of the Proteomics Committee of the Chinese Society of Biochemistry and Molecular Biology
Young Member of the Glycoconjugate Committee of the Chinese Society of Biochemistry and Molecular Biology
Member of the Chromatography Committee of the Chinese Association for Testing and Analysis
Member of the Mass Spectrometry Committee of the Chinese Association for Testing and Analysis
Teaching activity
Basic of Chemical Biology
Experiments in analytical chemistry
Key Publications
Shiyun Ma, Yuying Liang, Haoru Song, Ting Wang, Yuxiao Zhang, Lei Zhang, Jian Chen*, Haojie Lu*, Ying Zhang* Living Cell Surfacome Lysine Footprinting (LiFT) Captures Virus-Induced Conformational dynamic and uncovers novel Influenza A Virus Host factors, J. Am. Chem. Soc., 2026,148, 2260−2272
Bin Fu, Jierong Chen, Xuejiao Liu, Jiale Li, Xisong Feng, Jun Wang, Yueyue Li, Yuxiao Zhang, Bing Gu*, Ying Zhang*, Haojie Lu* Large-Scale Serum N-glycomics Tracks N-Glycosyaltion Dynamics in Hepatocellular Carcinoma Progression and Enables Early Diagnosis. Nat. Commun., 2026 ,17, 1885
Guoli Wang, Shiyun Ma, Haoru Song, Xinze Li, Lei Zhang, Haojie Lu*, Ying Zhang*, A Chemoproteomic Approach for System-Wide and Site-Specific Uncovering of Functional Protein N-Glycosylation. J Am Chem Soc, 2025, 147,24127-24139
Yuhan Cai, Aixiang Bu, Shanying Han, Yajie Ding, Hao Zhang, Jie Sun, Yuanyuan Deng, Jingyuan Ma, Shangqian Wang, Yanhong Gu, Wenya Chang, Zhongze Gu, Zhuoying Xie*, Lianghai Hu* and Ying Zhang* A Chemical Glycoproteomic Approach Decrypts Urinary Extracellular Vesicle Surfaceome for Prostate Cancer Diagnosis and Grading. Angew Chem Int Ed, 2025, 64, e202509399
Yang Li, Bin Fu, Maoyu Wang, Weiyu Chen, Jiawei Fan, Yueyue Li, Xuejiao Liu, Zhensheng Zhang*, Haojie Lu*, Ying Zhang* Urinary Extracellular Vesicle N-glycomics Identifies Diagnostic Glycosignatures for Bladder Cancer Nat Commun, 2025, 16, 2292.
Yuying Liang, Jian Chen*, Daobin Feng, Shiyun Ma, Haoru Song, Ying Zhang*, Haojie Lu* Ultrafast Tyrosinase-Mediated Biotinylation of Living Cell Surface Analysis Unveils Novel Host Cell Surface Proteins Responsible for Influenza A Virus Entry., J Am Chem Soc, 2025, 147, 32263-32272.
Xin Feng, Ao Shen, Wei Zhang, Shengnan Jia, Anton Iliuk, Yuling Wang, Wenke Zhang, Ying Zhang*, W. Andy Tao*, Lianghai Hu* High-throughput Capture and in situ Protein Analysis of Extracellular Vesicles by Chemical Probe-based Array. Nat Prot, 2025, 20, 1057-1081
Ting Wang, Shiyun Ma, Yang Liu, Lei Zhang, Ying Zhang*, Haojie Lu* A Chemical proteomics approach for mapping cell-surface functional lysine in living cell. Nat Commun 2024, 15, 2997
Ting Wang, Yuying Liang, Guoli Wang, Lei Zhang, Haojie Lu*, Ying Zhang*, Ultrafast and chemoselective biotinylation of living cell surface for time-resolved surfaceome analysis. Anal Chem, 2024, 96, 14448-14455.
Zhenyu Sun, Bin Fu, Guoli Wang, Lei Zhang, Ruofan Xu, Ying Zhang*, Haojie Lu* High-throughput site-specific N-glycoproteomics reveals glyco-signatures for liver disease diagnosis. Nat Sci Rev, 2023, 10, nwac059
