张莹

化学生物学

教授,博士生导师

  ying@fudan.edu.cn

  江湾化学楼A4022

  

  

学习工作经历

  • 2023.3-           复旦大学化学系研究员、教授

  • 2018.12-2023.2     复旦大学生物医学研究院研究员

  • 2017.1-2017.12     普渡大学生化系访问学者

  • 2012.12-2018.11     复旦大学生物医学研究院副研究员

  • 2009.7-2012.11     复旦大学生物医学研究院助理研究员

  • 2004.9-2009.6      复旦大学化学系,获得理学博士学位

学术任职

  • 中国生物化学与分子生物学会蛋白质组专业分会委员

  • 中国生物化学与分子生物学会糖复合物专业分会青年委员

  • 中国分析测试协会色谱专业委员会委员

  • 中国分析测试协会质谱专业委员会委员

获奖情况

  • 2021年教育部重大人才工程(青年学者)

  • 2019年上海市浦江人才

  • 2015年上海市青年科技启明星

研究兴趣

  • 蛋白质翻译后修饰(糖基化等)质谱分析方法

  • 化学蛋白质组学和功能蛋白质组学

  • 糖组学质谱分析方法

  • 组学分析方法及其在生命分析体系中的应用研究

授课情况

  • 化学生物学基础

  • 分析化学实验

代表性论文或专著

  • Shiyun Ma, Yuying Liang, Haoru Song, Ting Wang, Yuxiao Zhang, Lei Zhang, Jian Chen*, Haojie Lu*, Ying Zhang* Living Cell Surfacome Lysine Footprinting (LiFT) Captures Virus-Induced Conformational dynamic and uncovers novel Influenza A Virus Host factors, J. Am. Chem. Soc., 2026,148, 2260−2272

  • Bin Fu, Jierong Chen, Xuejiao Liu, Jiale Li, Xisong Feng, Jun Wang, Yueyue Li, Yuxiao Zhang, Bing Gu*, Ying Zhang*, Haojie Lu* Large-Scale Serum N-glycomics Tracks N-Glycosyaltion Dynamics in Hepatocellular Carcinoma Progression and Enables Early Diagnosis. Nat. Commun., 2026 ,17, 1885

  • Guoli Wang, Shiyun Ma, Haoru Song, Xinze Li, Lei Zhang, Haojie Lu*, Ying Zhang*, A Chemoproteomic Approach for System-Wide and Site-Specific Uncovering of Functional Protein N-Glycosylation. J Am Chem Soc, 2025, 147,24127-24139

  • Yuhan Cai, Aixiang Bu, Shanying Han, Yajie Ding, Hao Zhang, Jie Sun, Yuanyuan Deng, Jingyuan Ma, Shangqian Wang, Yanhong Gu, Wenya Chang, Zhongze Gu, Zhuoying Xie*, Lianghai Hu* and Ying Zhang* A Chemical Glycoproteomic Approach Decrypts Urinary Extracellular Vesicle Surfaceome for Prostate Cancer Diagnosis and Grading. Angew Chem Int Ed, 2025, 64, e202509399

  • Yang Li, Bin Fu, Maoyu Wang, Weiyu Chen, Jiawei Fan, Yueyue Li, Xuejiao Liu, Zhensheng Zhang*, Haojie Lu*, Ying Zhang* Urinary Extracellular Vesicle N-glycomics Identifies Diagnostic Glycosignatures for Bladder Cancer Nat Commun, 2025, 16, 2292.

  • Yuying Liang, Jian Chen*, Daobin Feng, Shiyun Ma, Haoru Song, Ying Zhang*, Haojie Lu* Ultrafast Tyrosinase-Mediated Biotinylation of Living Cell Surface Analysis Unveils Novel Host Cell Surface Proteins Responsible for Influenza A Virus Entry., J Am Chem Soc, 2025, 147, 32263-32272.

  • Xin Feng, Ao Shen, Wei Zhang, Shengnan Jia, Anton Iliuk, Yuling Wang, Wenke Zhang, Ying Zhang*, W. Andy Tao*, Lianghai Hu* High-throughput Capture and in situ Protein Analysis of Extracellular Vesicles by Chemical Probe-based Array. Nat Prot, 2025, 20, 1057-1081

  • Ting Wang, Shiyun Ma, Yang Liu, Lei Zhang, Ying Zhang*, Haojie Lu* A Chemical proteomics approach for mapping cell-surface functional lysine in living cell. Nat Commun 2024, 15, 2997

  • Ting Wang, Yuying Liang, Guoli Wang, Lei Zhang, Haojie Lu*, Ying Zhang*, Ultrafast and chemoselective biotinylation of living cell surface for time-resolved surfaceome analysis. Anal Chem, 2024, 96, 14448-14455.

  • Zhenyu Sun, Bin Fu, Guoli Wang, Lei Zhang, Ruofan Xu, Ying Zhang*, Haojie Lu* High-throughput site-specific N-glycoproteomics reveals glyco-signatures for liver disease diagnosis. Nat Sci Rev, 2023, 10, nwac059