To date, natural products are still the main source of human medicine. In the post genome era, there is a renewed interest on natural product studies because genome information revealed that we touch only a tiny portion of the natural product pools. In the presentation, we will summarize our recent efforts in natural product based drug discovery efforts in the following three areas:

1. Molecular discovery: in this area, we focus on how to efficiently build natural product library that is not feasible through traditional approach;

2. Process chemistry: in this area, we will summarize some of our recent efforts on developing fermentation based production methods for high value products.

   Animal model: for drug discovery efforts, proper animal is crucial. In this portion, we will discuss our efforts on studying ageing related diseases.