学科进展系列报告

Single-Molecule Studies of Protein Conformational Dynamics

报告人：Prof. Haw Yang

Chemistry Department, Princeton University

Proteins are remarkable molecular machines capable of carrying out complicated tasks amid the ubiquitous thermal noise. In this presentation, we sketch the state-of-the-art high-resolution time-dependent single-molecule measurements—photon-by-photon spectroscopy enabled by rigorous statistical analysis where information carried by each detected photon is explicitly taken into account. Using these new tools, we show how a protein is able to utilize stochastic motions to accomplish its function. Specifically, we show how the venerable “induced-fit” model for protein-substrate interaction should be revised, how Mycobacterium tuberculosis has evolved to insert novel structural motifs to prolong its virulence, and the discovery of a compound molecular logic from a single small protein. If time permits, we will also discuss the next challenges in protein dynamics and possible approaches to overcoming them.

时间：6月13日下午3点

地点：化学楼A3030

邀请人：王文宁