Research Interests

• Microbial Transformation technologies

• Studies on metabolic pathways of natural products and the preparation of active metabolites by using microbial conversion technologies.

• Biological activity and mechanism study

• A variety of disease models, such as viruses (influenza, hepatitis B, herpes, Coxsackie, respiratory syncytial) and in vivo models, bacteria (Staphylococcus aureus, Escherichia coli, Candida albicans, pneumococcal), arthritis model (acute arthritis, adjuvant arthritis, type II collagen in rheumatoid arthritis), and liver disease (chemical and immunological damage, fatty liver, liver fibrosis), etc. to carry out candidate compounds screening, mechanism studies, as well as research and development of new drugs.

Biography

• 1999.9-2003.6    School of pharmacy, Fudan University, Under-graduate course, (Bachelor degree)

• 2003.9-2008.6    Department of Biosynthetic Drug, School of Pharmacy, Fudan University, graduate course (Ph.D degree)

• 2008.7-2010.3    Project manager, Zhejiang Hisun Pharmaceutical Co. Ltd (China)

• 2010.4-2011.10  Visiting scholar, Biology Science department, Ohio University (U.S.A)

• 2012.12-now      Lecturer, Department of Chemistry, Fudan University

Teaching

• Organic synthesis experiment

• Medicinal chemistry

Key Publications

1. Yang Zong, Zhuo Lei, Shang-Bo Yu*, Ling-Yu Zhan g, Yan Wu, Ke Feng, Qiao-Yan Qi, Yamin Liu, Yajie Zhu, Peng Guo, Wei Zhou*, Dan-Wei Zhang, Zhan-Ting Li*. Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo. Journal Medicinal Chemistry, 2024, 67, 5, 3860–3873.

2. YanWu, JingyuYang, Sheng-Yi Zhuang, Shang-BoYu, Yang Zong, Yue-Yang Liu, Gang Wu, Qiao-Yan Qi, Hui Wang, Jia Tian, Wei Zhou*, Da Ma*, Dan-Wei Zhang*, Zhan-Ting Li*. Macrocycles and Acyclic Cucurbit[n]urils as Pseudo[2]catenane Partners for Long-Acting Neuromuscular Blocks and Rapid Reversal In Vivo. Journal Medicinal Chemistry, 2024, 67, 2176-2187.

3. Wang Xinhua¹; Zhou Wei¹; Xie Wenlin; Chen Qi; Wu Jie*. Generation of (E)-β- trifluoromethyl vinylsulfonohydrazides under photocatalysis and their anti-bacteria activity. Chinese Chemical Letters, 2023, 34, 107984.

4. Hong-Kun Liu, Furong Lin, Shang-Bo Yu*, Yan Wu, Shuai Lu, Yue-Yang Liu, Qiao-Yan Qi, Jin Cao, Wei Zhou*, Xiaopeng Li, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li*, Da Ma*. Highly Water-Soluble Cucurbit[8]uril Derivative as a Broad-Spectrum Neuromuscular Block Reversal Agent. Journal Medicinal Chemistry, 2022, 65, 16893−16901.

5. Yan Wu, Yue-Yang Liu, Hong-Kun Liu, Shang-Bo Yu, Furong Lin, Wei Zhou*, Hui Wang, Dan-Wei Zhang*, Zhan-Ting Li*, Da Ma*. Flexible organic frameworks sequester neuromuscular blocking agents in vitro and reverse neuromuscular block in vivo. Chemical Science, 2022, 13, 9243–9248.

6. Xuefeng Wang, Jun Zhang, Qi Chen, Wei Zhou*, Jie Wu*. Generation of sulfonylureas under photoredox catalysis and their biological evaluations. Chinese Chemical Letters, 2022, 33, 4860–4864.

7. Furong Lin, Shang-Bo Yu,* Yue-Yang Liu, Chuan-Zhi Liu, Shuai Lu, Jin Cao, Qiao-Yan Qi, Wei Zhou,* Xiaopeng Li, Yi Liu, Jia Tian, Zhan-Ting Li*. Porous Polymers as Universal Reversal Agents for Heparin Anticoagulants through an Inclusion Sequestration Mechanism. Advanced Materials, 2022, 34, 2200549.

8. Yamin Liu, Ze-Kun Wang, Zhong-Zheng Gao, Yang Zong, Jian-Da Sun, Wei Zhou*, Hui Wang, Da Ma, Zhan-Ting Li*, Dan-Wei Zhang*. Porous organic polymer overcomes the post-treatment phototoxicity of photodynamic agents and maintains their antitumor efficiency. Acta Biomaterialia, 2022, 150, 254–264.

9. Yue-Yang Liu, Ze-Kun Wang, Shang-Bo Yu, Yamin Liu, Hui Wang, Wei Zhou*, Zhan-Ting Li*, Dan-Wei Zhang*. Conjugating aldoxorubicin to supramolecular organic frameworks: polymeric prodrugs with enhanced therapeutic efficacy and safety. Jounal of Material Chemistry B, 2022, 10, 4163–4171.

10. Jun Zhang, Xuefeng Wang, Qi Chen, Jianhe Liu*, Wei Zhou*, Jie Wu*. (E)-β -Trifluoromethyl vinylsulfones as antitumor agents: Synthesis and biological evaluations.  European Journal of Medicinal Chemistry, 2022, 232, 114197.

11. Yang Zong, Yan-Yan Xu, Yan Wu, Yamin Liu, Qian Li, Furong Lin*, Shang-Bo Yu*, Hui Wang, Wei Zhou*, Xing-Wen Sun, Dan-Wei Zhang and Zhan-Ting Li*. Porous dynamic covalent polymers as promising reversal agents for heparipn anticoagulants. Jounal of Material Chemistry B, 2022, 10, 3268-3276.

12. Shuwen Han, Chunlin Zhuang, Wei Zhou*，Fener Chen*. Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β. Marine Drugs, 2021, 19, 149.

13. Yun-Yan Kuang, Xuan Gao, Yi-Jun Niu, Xun-Long Shi，Wei Zhou*. Polymorphic characterization, pharmacokinetics, and anti-Inflammatory activity of ginsenoside compound K polymorphs. Molecules, 2021, 26, 1983.

14. Jiale Lin, Zekun Wang, Ziyue Xu, Lei Wei; Yunchang Zhang*, Hui Wang, Danwei Zhang, Wei Zhou*, Yuebiao Zhang, Yi Liu*; Zhanting Li*. Water-soluble flexible organic frameworks that include and deliver proteins. Journal of the American Chemical Society, 2020, 142, 3577–3582.

15. Haosha Tang, Yunyan Kuang, Julan Zeng, Xiaofang Li, Wei Zhou*, Yuan Lu*. Combinatorial synthesis and biological evaluations of (E)-β-trifluoromethyl vinylsulfones as antitumor agents. RSC Advances, 2019, 9, 31474.

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