Research Interests

• Flow Chemistry, Microreactor

• Asymmetric total synthesis of natural products and pharmaceuticals

• C-H bond functionalization

Biography

• 2022.01-NowAssociate Professor, Department of Chemistry, Fudan University

• 2021.09-2021.12Associate Professor, School of Chemical Engineering, East China University of Science and Technology

• 2017.10-2021.08Lecturer, School of Chemical Engineering, East China University of Science and Technology

• 2014.07-2017.09Lecturer, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University

• 2012.09-2013.09Visiting Ph.D. Student in Organic Chemistry, The Scripps Research Institute (CA)，Advisor: Prof. Jin-Quan Yu

• 2009.09-2014.06Ph.D. in Applied Chemistry, Nanjing University of Science and Technology, Advisor: Prof. Chun Cai

• 2005.09-2009.06B.Sc. in Pharmaceutical Engineering, Nanjing University of Science and Technology

Teaching

• Organic Synthesis-II

Key Publications

1. Q. Li, M. J. Liu, Y. J. Zhang, L. Wan,* F. E. Chen.* Scalable and integrated four-step continuous-flow synthesis of ibuprofen using a zinc-catalyzed 1,2-aryl migration strategy. ACS Sustainable Chem. Eng.2024, 12, 8512-8520.

2. S. Q. Huang, R. Q. Hao, Q. Li, L. Wan,* F. E. Chen.* Selective C–H functionalizations of arenes catalyzed by poly NHC–Pd in flow. React. Chem. Eng.2024, 9, 1641-1645.

3. Z. N. Li, S. Q. Huang, Y. Tao, M. F. Jiang, D. Cheng, L. Wan,* F. E. Chen.* An integrated five-step continuous flow synthesis of 2-(1-cyclohexenyl)ethylamine: a key intermediate for morphinans. React. Chem. Eng.2023, 8, 1882-1887.

4. L. Wan, M. F. Jiang, D. Cheng, M. J. Liu, F. E. Chen. Continuous flow technology-a tool for safer oxidation chemistry. React. Chem. Eng.2022, 7, 490-550.

5. L. Zhang, X. F. Bo, H. L. Yao, M. M. Mao, L. Wan,* Z. Xin*. Zinc-catalyzed alkylation of aromatic amines in continuous flow. Org. Process Res. Dev. 2020, 24, 2078-2084.

6. K. Qiao, D. Zhang, K. Zhang, X. Yuan, M. W. Zheng, T. F. Guo, Z. Fang, L. Wan*, K. Guo*. Iron(II)-catalyzed C-2 cyanomethylation of indoles and pyrroles via direct oxidative crossdehydrogenative coupling with acetonitrile derivatives. Org. Chem. Front.2018, 5, 1129-1134.

7. L. Wan, K. Qiao, X. Yuan, M. W. Zheng, B. B. Fan, Z. C. Di, D. Zhang, Z. Fang, K. Guo*. Nickel-catalyzed regioselective C-H bond mono- and bis-nitration of aryl oxazolines with TBN as nitro source. Adv. Syn. Cat.2017, 359, 2596-2604.

8. L. Wan, X. N. Sun, S. J. Shi, J. W. Zhang, X. Li, Z. J. Li, K. Guo*. An efficient synthesis of N-substituted phthalimides using SiO2-tpy-Nb as heterogeneous and reusable catalyst. Catal. Commun.2017, 88, 30-34.

9. L. Wan, W. T. Zhu, K. Qiao, X. N. Sun, Z. Fang, K. Guo*. C3 Alkylation of indoles catalyzed by carbocations under continuous-flow conditions. Asian J. Org. Chem.2016, 5, 920-926.

10. G. Li, L. Wan, G. F. Zhang, D. Leow, J. Spangler, J.-Q. Yu. Pd(II)-Catalyzed C−H functionalizations directed by distal weakly coordinating functional groups. J. Am. Chem. Soc.2015, 137, 4391-4397.

11. L. Wan, N. Dastbaravardeh, G. Li, J.-Q. Yu. Cross-coupling of remote meta-C–H bonds directed by an U-shaped template. J. Am. Chem. Soc.2013, 135, 18056-18059.

12. G. Li, D. Leow, L. Wan, J.-Q. Yu. Ether-directed ortho-C–H olefination with a palladium(II)/monoproctected amino acid catalyst. Angew. Chem., Int. Ed. 2013, 52, 1245-1247.