Research Interests

• Discovery and Application of Novel Enzymatic and Biocatalytic Reaction

• Chiral Drug and Chiral Technology

Biography

• 2003.9-2007.6           BSc, Department of Chemistry, Zhejiang University

• 2007.9-2012.8           PhD, Department of Chemistry, University of Alberta

• 2012.11-2016.10       Post-Doc, Institute for Genomic Biology, University of Illinois at Urbana-Champaign

• 2016.11-                    Associate Professor, Department of Chemistry, Fudan University

Key Publications

1. Wu, X.; Hou, F.; Zhang, L.; Wu, Q.; Huang, Z.;* Chen, F.* Enantiocomplementary Access to Silicon-Stereogenic Silacyclohexenones via Ene-Reductase-Catalyzed Desymmetrization of Silacyclohexadienones. ACS Catal.2025, 15, 10982-10990.

2. Li, Y.;# Yang, Y.;# Zhang, M.; Yue, X.; Guo, R.-T.;* Huang, Z.;* Chen, F.* Mutagenesis of a Single Site Inverts the Stereopreference of Imine Reductase. ACS Catal.2025, 15, 2192-2199.

3. Wu, X.; Yang, L.; Liu, Z.; Zhang, K.; Huang, Z.;* Chen, F.* Ene-Reductase-Catalyzed Enantioselective Desymmetrization of Cyclohexadienones: Straightforward Access to All-Carbon Quaternary Stereocenters. ACS Catal.2024, 14, 6194-6202.

4. Zhu, K.; Jiang, M.; Ye, B.; Zhang, G.; Li, W.; Tang, P.; Huang, Z.;* Chen, F.* A Unified Strategy to Prostaglandins: Chemoenzymatic Total Synthesis of Cloprostenol, Bimatoprost, PGF₂, Fluprostenol, and Travoprost Guided by Biocatalytic Retrosynthesis. Chem. Sci.2021, 12, 10362-10370.

5. Guo, Z.; Wu, Z.; Wu, X.; Zhang, L.; Huang, Z.;* Chen, F.* Ketoreductase-Catalyzed Dynamic Reductive Kinetic Resolution of Sterically Hindered 2-Aryl-1,5-Benzothiazepin-3,4(2H,5H)-Diones: Asymmetric Synthesis of a Key Diltiazem Precursor and Its Analogues. Green Chem. 2024, 26, 7818-7824.

6. Hu, P.; Wu, X.; Zhang, Y.; Liu, M.; Tao, Y.; Huang, Z.;* Chen, F.* Engineered Ketoreductase-Catalyzed Stereoselective Reduction of Ethyl 2’-Ketopantothenate and Its Analogues: Chemoenzymatic Synthesis of D-Pantothenic Acid. Green Chem.2024, 26, 2124-2134.

7. Zhang, Y.; Liu, M.; Yang, Z.; Lin, J.;* Huang, Z.;* Chen, F.* Batch and Continuous Flow Asymmetric Synthesis of Anabolic-Androgenic Steroids via a Single-Cell Biocatalytic Δ1-Dehydrogenation and C17-Carbonyl Reduction Cascade. Green Chem.2023, 25, 3223-3235.

8. Ye, Y.; Tao, Y.; Hu, P.; Zhang, Y.; Zhang, L.; Wu, X.;* Huang, Z.;* Chen, F.* Asymmetric Synthesis of Chiral Benzoins Enabled by Engineered Ketoreductase-Catalyzed Stereoselective Reduction of Benzils. ACS Sustainable Chem. Eng.2024, 12, 11605-11612.

9. Liu, J.; Wu, X.; Li, Z.; Huang, Z.;* Chen, F.* Engineered Monoamine Oxidase-Catalyzed Deracemization of Sterically Hindered Acylaminomethyl-tetrahydroisoquinoline: Asymmetric Synthesis of (R)‑(−)-Praziquantel and Its Analogues. ACS Sustainable Chem. Eng. 2023, 11, 7552-7559.

10. Li, Z.; Yang, H.; Liu, J.; Huang, Z.;* Chen, F.* Application of Ketoreductase in Asymmetric Synthesis of Pharmaceuticals and Bioactive Molecules: An Update (2018-2020). Chem. Rec. 2021, 21, 1611-1630.