Research Interests

• Discovery and Application of Novel Enzymatic and Biocatalytic Reaction

• Chiral Drug and Chiral Technology

Biography

• 2003.9-2007.6           BSc, Department of Chemistry, Zhejiang University

• 2007.9-2012.8           PhD, Department of Chemistry, University of Alberta

• 2012.11-2016.10       Post-Doc, Institute for Genomic Biology, University of Illinois at Urbana-Champaign

• 2016.11-                    Associate Professor, Department of Chemistry, Fudan University

Key Publications

1. Li, Z.; Wang, Z.; Wang, Y.; Wu, X.; Lu, H.; Huang, Z.;* Chen, F.* Substituent Position-Controlled Stereoselectivity in Enzymatic Reduction of Diaryl- and Aryl(heteroaryl)methanones. Adv. Synth. Catal.2019, 361, 1859-1865.

2. Wu, X.; Huang, Z.;* Wang, Z.; Li, Z.; Wang, J.; Lin, J.;* Chen, F.* Asymmetric Synthesis of a Key Dextromethorphan Intermediate and Its Analogues Enabled by a New Cyclohexylamine Oxidase: Enzyme Discovery, Reaction Development, and Mechanistic Insight. J. Org. Chem.2020, 85, 5598-5614.

3. Wang, Z.; Zeng, Y.; Wu, X.; Li, Z.; Tao, Y.; Yu, X.; Huang, Z.;* Chen, F.* Access to Chiral α-Substituted-b-Hydroxy Arylphosphonates Enabled by Biocatalytic Dynamic Reductive Kinetic Resolution. Org. Biomol. Chem.2020, 18, 2672-2677.

4. Wang, Z.; Wu, X.; Li, Z.; Huang, Z.;* Chen, F.* Ketoreductase Catalyzed Stereoselective Bioreduction of α-Nitro Ketones. Org. Biomol. Chem.2019, 17, 3575-3580.

5. Li, Z.; Wang, Z.; Meng, G.; Lu, H.; Huang, Z.;* Chen, F.* Identification of an Ene Reductase from Yeast Kluyveromyces Marxianus and Application in the Asymmetric Synthesis of (R)-Profen Esters. Asian J. Org. Chem.2018, 7, 763-769.

6. Huang, Z.; Wang, K. K. A.; van der Donk, W. A.* New Insights into the Biosynthesis of Fosfazinomycin. Chem. Sci.2016, 7, 5219-5223.

7. Huang, Z.; Wang, K. K. A.; Lee, J.; van der Donk, W. A.* Biosynthesis of Fosfazinomycin Is a Convergent Process. Chem. Sci.2015, 6, 1282-1287.