EN
Haojie Lu
Analytical Chemistry
Professor
luhaojie@fudan.edu.cn
Room 311 Mingdao building, 131 Dong'an
86-21-54237618
Research Interests
Novel mass spectrometric technologies for separation and identification of low-abundance proteins and post-translational proteins
Novel mass spectrometric technologies for relative and absolute quantification of proteome
Novel mass spectrometric technologies for profiling of biomarker for disease tissue
Prizes and awards
2005 Winner of the first prize of Education Ministry of Natural Science Prize nomination (fourth)
2005 Winner the Century Star from Fudan University（comprehensive）
2006 Winner of Education Ministry's New Century Excellent Talents Supporting Plan
2006 Sponsored by Shanghai Rising-Star Program
2008 Sponsored by Shanghai Shuguang scholars Fund
2008 Obtained the Meiji dairy life science Excellence Award
2009 Winner of Young chemist Award from China Chemical Society
2009 Awarded as the university distinguished professor of Shanghai (Eastern Scholar)
2010 Supported by The National Science Fund for Distinguished Young Scholars
2013 Awarded the Eastern Scholar tracking program
Biography
1992.09-1996.07 Xiamen University obtained a Bachelor's degree
1996.09-2001.07 Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences， obtained Ph.D
2001.09-2003.07 Shanghai Institute of Organic Chemistry, Chinese Academy of Science, postdoctoral
2003.09-present Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, assistant professor, associate professor and professor
2006.09-2007.09 School of Medicine at University of California, Los Angeles (UCLA), visiting scholar
Teaching
Analytical chemistry、New technology and new method of proteomics
Key Publications
Liu Xuejiao , Fu Bin , Zheng Dongdong , Zhang Ying*, Lu Haojie *, A High-Throughput N-Glycan Analysis Strategy with Targeted Mass Spectrometry (HTnGQs-Target) for Liver Disease Diagnosis. Chem Sci, 2026, 17, 364-372
Fu Bin, Chen Jierong, Liu Xuejiao , Li Jiale , Feng Xisong ,Wang Jun, Li Yueyue, Zhang Yuxiao, Gu Bing*, Zhang Ying*, Lu Haojie* Large-Scale and multi-cohort Serum N-glycomics Tracks N-Glycosyaltion Dynamics in Hepatocellular Carcinoma Progression and Enables Early Diagnosis Nat Commun, 2026, 17, 1885
Wang Jun, Gu Chenzheng, Wang Pengxiang, Xian Jing-Rong, Wang Hao, Shang Anquan, Zhong Yuchen, Zheng Wenjing, Cheng Jianwen, Yang Wenjing, Zhou Jian, Fan Jia, Guo Wei, Yang Xinrong, Lu Haojie* Integrative Proteomic Profiling of Tumor and Plasma Extracellular Vesicles Identifies a Diagnostic Biomarker Panel for Colorectal Cancer. Cell Rep Med, 2025, 6,5, 102090
Yuying Liang, Jian Chen*, Daobin Feng, Shiyun Ma, Haoru Song, Ying Zhang*, Haojie Lu* Ultrafast Tyrosinase-Mediated Biotinylation of Living Cell Surface Analysis Reveals Novel Cell Surface Proteins Responsible for Influenza A Virus Entry, J Am Chem Soc, 2025,147, 35, 32263-32272.
WangGuoli , Ma Shiyun, Song Haoru, Li Xinze , Zhang Lei, Lu Haojie*, Zhang Ying*, A Chemoproteomic Approach for System-Wide and Site-Specific Uncovering of Functional Protein N-Glycosylation. J Am Chem Soc, 2025, 147, 27, 24127–24139
Feng Xiaoxiao, Li Jing, Wang Jun, Liang Yuying, Fu Bin, Sun Zhenyu, Yao Jun, He Juan, Nie Aiying, Wei Liming, Feng Weiwei*, Lu Haojie* SiaQuant unveils serum α2,3/α2,6 sialylation heterogeneities and predicts neoadjuvant chemotherapy response in locally advanced cervical cancer. Anal Chem, 2025, 97, 14, 7682–7691
Li Zhonghua*, Du Qi, Feng Xiaoxiao, Song Xuezheng, Ren Zhenggang, Lu Haojie * A One-Step Enzymatic Strategy for Efficient Imaging and Mapping of Tumor- Associated Tn Antigen. J Am Chem Soc, 2024, 146, 30, 20539–20543
Wang Ting, Ma Shiyun, Ji Guanghui, Wang Guoli, Liu Yang, Zhang Lei, Zhang Ying * and Lu Haojie* A Chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun, 2024, 15, 2997
Xiong Yingying, Lu Zhuoer, Shao Yuyin, Meng Peiyi, Wang Guoli, Zhou Xinwen, Yao Jun, Bao Huimin*, and LuHaojie* Multifunctional materials enable ultrafast and large-scale enrichment of glycopeptides and reveal distinct spatial patterns upon oxidative stress. Nat Sci Rev, 2024, DOI:10.17632/2v8zncksb2.1
Sun Zhenyu, Fu Bin, Wang Guoli, Zhang Lei, Xu Ruofan, Zhang Ying *, Lu Haojie * High-throughput site-specific N-glycoproteomics reveals glyco-signatures for liver disease diagnosis. Nat Sci Rev, 2023, 10, nwac059
