EN
Xiangshi Tan
Chemical Biology
Professor, Doctoral Tutor
xstan@fudan.edu.cn
Room A4023, Chemistry Building, Department of Chemistry, Fudan University 2005 Songhu Road, Yangpu District, Shanghai 200438, China
021-31249208
Research Interests
Bioinorganic Chemistry, Chemical Biology of Metalloproteins and Metalloenzymes;
Structural Basis and mechanism for human soluble guanylate cyclase to mediate NO-signalling; Regulation mechanism of metal ions homeostasis in AD brain;
Trafficking, metabolism and regulation of metal ions in cells;
Functional design of metalloproteins and metalloenzymes.
Prizes and awards
Faculty of 1000 member in Biochemistry 2013
Member of Sigma Xi, 2002
JSPS and STA research fellowship, 1998-2000
Royal Society research fellowship, 1997
Biography
2007-present Fudan University, Professor
2000-2007 Texas A & M University, Research Scientist
1998-2000 Japan，Ibaraki University，JASP Research Scientist
1997-1998 UK，Edinburgh University, Royal Society Research Scientist
1996-1997 France, CEA-Grenoble, Postdoctoral Research Associate
1993-1996 PhD, Nanjing University
1989-1992 M.S., East China Normal University
1982-1986 B.S., Liaocheng University
Teaching
Graduate students: 《BioinorganicChemistry/ Protein Chemistry》, 《Progress in Bioinorganic Chemistry》
Undergraduate students: 《Metals in Biology and Diseases》, 《Research Design and Training 》
Key Publications
Jie Pan, Qiming Xu, Ying-Wu Lin, Fangfang Zhong and Xiangshi Tan*, Human soluble guanylate cyclase as a nitric oxide sensor for NO-signalling reveals a novel function of nitrite reductase，Chem. Commun., 49, 7454-7456，2013.
Xiaoping Lv, Wei Li, Ying Luo, Dandan Wang, Cuiqing Zhu, Zhong-Xian Huang and Xiangshi Tan*, Exploring the differences between mouse mAβ1–42 and human hAβ1–42 for Alzheimer's disease related properties and neuronal cytotoxicity，Chem. Commun., 49, 5865-5867，2013.
Yi Liu, Qingli Wang, Yaozhu Wei, Ying-Wu Lin, Wei Li, Ji-Hu Su, Zhen Wang, Yang Tian, Zhong-Xian Huang and Xaingshi Tan*, Functional conversion of nickel-containing metalloproteins via molecular design: from a truncated acetyl-coenzyme A synthase to a nickel superoxide dismutase, Chem. Commun., 49, 1452-145, 2013.
Wei Li, Hongfei Wang, Zheng Chen, Qing Ye, Yang Tian, Xin Xu, Zhong-xian Huang, Pingwei Li, Xiangshi Tan*, Probing the metal specificity mechanism of superoxide dismutase from human pathogen Clostridium difficile, Chem. Commun., 50, 584-586, 2014.
Ying Luo, Yuxia Xu, Qingui Bao, Zhichhun Ding, Cuiqing Zhu, Zhong-Xian Huang, Xiangshi Tan*, The molecular mechanism for human metallothionein-3 to protect against the neuronal cytotoxicity of A1–42 with Cu ions, J Biol Inorg Chem, 18(1):39-47, 2013.
Yi Liu, Xiaofei Zhu, Feng Wang, Pingwei Li, Zhong-xian Huang and Xiangshi Tan*, Probing the role of the bridging C509 between the [Fe4S4] cubane and [NipNid] centre in the A-Cluster of Acetyl-Coenzyme A Synthase, Chem. Commun., 47(4), 1291-1293, 2011.
Yi Liu, Feng Wang, Pingwei Li, and Xiangshi Tan*, Insights into the Mechanistic Role of the [Fe4S4] Cubane in the A-Cluster {[Fe4S4]-(SR)-[NipNid]} of Acetyl-Coenzyme A Synthase, ChemBioChem., 12(9):1417-1421, 2011.
Xiangshi Tan, Marlene Martinho, Audria Stubna, Paul A. Lindahl, Eckard Münk, Mössbauer Evidence for an Exchange-Coupled {[Fe4S4]1+:Nip1+} A-cluster in Isolated Alpha Subunits of Acetyl-Coenzyme A Synthase/Carbon Monoxide Dehydrogenase, J. Am. Chem. Soc. , 130, 6712-6713, 2008.
Xiangshi Tan, Ivan V. Surovtsev, and Paul A. Lindahl, Kinetics of CO Insertion and Acetyl Group Transfer Steps, and a Model of the Acetyl-CoA Synthase Catalytic Mechanism, J. Am. Chem. Soc. 128(37), 12331-12338, 2006.
Xiangshi Tan, Huay-Keng Loke, Shawn Fitch and Paul A. Lindahl, The Tunnel of the Acetyl-CoA Synthase/Carbon Monoxide Dehydrogenase Regulates Delivery of CO to the Active Site, J. Am. Chem. Soc. 127, 5833-5836, 2006.
