包慧敏

分析化学

副教授

baohm@fudan.edu.cn

化学楼 A4021室

研究兴趣

  • 基于生物正交标签的化学蛋白质组学技术;  

  • 基于核酸功能材料的蛋白质组学方法;  

  • 化学蛋白质组学技术在新生蛋白质组学和生物医学中的应用

获奖情况

  • 2010年 复旦大学复华奖(三等奖)    

  • 2015年 复旦大学 “研究生十佳辅导员”   

  • 2016年 复旦大学 “优秀教工支部”(任支部书记)   

  • 2019年度上海药学科技奖(基础研究类)二等奖,排名2

学习工作经历

  • 2014.01-至今     复旦大学,副教授   

  • 2001.07-2013.12  复旦大学,助教,讲师   

  • 1999.07-2001.06  原上海医科大学,基础医学院 助教   

  • 2012.04-2013.04  美国北卡莱罗那大学(教堂山分校)UNC-CH,访问学者   

  • 2002.09-2008.06  复旦大学,化学系,分析化学博士   

  • 1995.09-1999.06  华东师范大学,化学系,理学学士

授课情况

  • 分析化学   

  • 无机化学与化学分析实验   

  • 仪器分析与物理化学实验   

  • 食品安全

代表性论文或专著

  • Yingying Xiong, Zhuoer Lu, Yuyin Shao, Peiyi Meng, Guoli Wang, Xinwen Zhou, Jun Yao, Huimin Bao*, Haojie Lu*, Rapid and large-scale glycopeptides enrichment strategy based on chemical ligation. National Science Review, 2024, in press. https://doi.org/10.1093/nsr/nwae341

  • Peiyi Meng, Yuyin Shao, Yingying Xiong, Lei Zhang, Huimin Bao*, Haojie Lu*, Peptide- and Protein-Level Combined Strategy for Analyzing Newly Synthesized Proteins by Integrating Tandem Orthogonal Proteolysis with Cleavable Bioorthogonal Tagging. Anal. Chem. 2023, 95, 628−637.

  • Yuyin Shao, Huimin Bao,* Lixiang Ma, Wenjuan Yuan, Lei Zhang, Jun Yao, Peiyi Meng, Ye Peng, Siwen Zhang, Ting Cao, and Haojie Lu.* Enhancing Comprehensive Analysis of Newly Synthesized Proteins Based on Cleavable Bioorthogonal Tagging. Anal. Chem. 2021, 93, 27, 9408–9417.

  • Huimin Bao, Liqi Xie, Haojie Lu.* Research advances of enrichment approaches based on chemical reactions in glycoproteomics. Chinese Journal of Chromatography, 2016, 34(12): 1145-1153.

  • Huimin Bao, Luyan Zhang, Gang Chen.* Immobilization of trypsin via graphene oxide-silica composite for efficient microchip proteolysis. J. Chromatography A, 2013, 1310: 74-81.  

  • Huimin Bao, Shuang Liu, Luyan Zhang, Gang Chen.* Efficient sample proteolysis based on a microchip containing a glass fiber core with immobilized trypsin. Microchim Acta, 2012, 179: 291–297.

  • Huimin Bao, Qiwen Chen, Luyan Zhang, Gang Chen.* Immobilization of trypsin in the layer-by-layer coating of graphene oxide and chitosan on in-channel glass fiber for microfluidic proteolysis. Analyst, 2011, 136(24), 5190-5196.

  • Huimin Bao, Peiming Song, Qingping Liu, Yinkun Liu, Dong Yun,Hexige Saiyin, Ruyun Du, Yang Zhang, Huizhi Fan, Pengyuan Yang, Xian Chen.* Quantitative proteomic analysis of a paired human liver healthy versus carcinoma cell lines with the same genetic background to identify potential hepatocellular carcinoma markers. Proteomics Clin. Appl. 2009, 3: 705–719.

  • Huimin Bao, Ting Liu, Luyan Zhang, Gang Chen.* Infrared-assisted proteolysis using trypsin-immobilized silica microspheres for peptide mapping. Proteomics. 2009, 9: 1114–1117.