刘小文

有机化学

青年研究员,硕士生导师

liuxw@fudan.edu.cn

复旦大学手性分子催化与合成工程中心A212室

15112131663

研究兴趣

  • 蛋白稳定化研究

  • 蛋白稳定化研究

学习工作经历

  • 2022.10- 至今   复旦大学化学系,青年研究员

  • 2020.10-2022.9   暨南大学基础医学与公共卫生学院,副教授

  • 2017.3-2020.9    暨南大学基础医学与公共卫生学院,副研究员

  • 2012.11-2016.11   德国慕尼黑大学药学院,获理学博士学位 (导师:Ernst Wagner院士)

  • 2009.7-2012.7    苏州大学功能纳米软物质研究院,获理学硕士学位(导师:刘庄教授)

  • 2009.3-2009.6    苏州吉玛基因有限公司,研发工程师

  • 2008.6-2008.12   东莞万德电子制品有限公司,研发工程师

  • 2004.9-2008.6    南昌航空大学环境与化学工程学院,获理学学士学位

代表性论文或专著

  • X. Xin, Y. Liu, L. Guo, H.Wang, D. Lu, Y. Chang, M. Wan, Y. Zhang, Y. Shan, Q. Zhang, X. Liu*, F. Gao*. Improvement of B cell responses by an HIV-1 amphiphilic polymer nanovaccine. Nano Lett., 2023, 23, 9, 4090–4094

  • X. Liu*, L. Zhao, B. Wu, F. Chen*. Improving solubility of poorly water-soluble drugs by protein-based strategy: a review. Int. J. Pharm., 2023, 634, 122704.  

  • X. Xin, J. Chen, L. Chen, J. Wang, X. Liu*, F. Chen*. Lyophilized insulin micelles for long-term storage and regulation of blood glucose for preventing hypoglycemia. Chem. Eng.J., 2022, 435, 134929.  

  • P. Zhou, X. Zhang, X. Xin, J. Yang, Q. Pan, C. Liu, Y. Liu, X. Yu, Z. Li*, G. Jiao*, X. Liu *.Click chemistry-conjugated protein-drug micelles with anti-ferroptotic and anti-inflammatory properties promote regeneration in spinal cord injury. Chem. Eng.J., 2022, 428, 132118.   

  • X. Zhang, P. Zhou, S. Zhuo, F. Zhang, J. Yu, X. Liu*. Protein nanogels with enhanced pH-responsive dynamics triggered by remote NIR for systemic protein delivery and programmable controlled release. Int. J. Pharm., 2021, 605, 120833.    

  • X. Xin, Y. Xu, H. Shi, X. Liu*. General method to stabilize mesophilic proteins in hyperthermal water. iSciecne, 2021, 24 (5), 102503.     

  • X. Xin, Z. Zhang, X. Zhang, J. Chen, X. Lin*, P. Sun*, X. Liu*. Bioresponsive nanomedicines based on dynamic covalent bonds. Nanoscale, 2021, 13 (27), 11712-11733.   

  • X. Liu, C. Wang *, Z. Liu *. Protein‐Engineered Biomaterials for Cancer Theranostics. Adv. Healthcare Mater., 2018, 7(20), 1800913.